Reference SummaryConover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9
Title |
Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A. |
Authors |
Conover CA; Bale LK; Mader JR; Mason MA; Keenan KP; Marler RJ |
Journal |
J Gerontol A Biol Sci Med Sci |
Volume |
65 |
Issue |
6 |
Year |
2010 |
Pages |
590-9 |
Abstract |
The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal circulating IGF-I levels. In this study, PAPP-A KO mice had significantly increased mean (27%), median (27%), and maximum (35%) life span compared with wild-type (WT) littermates. End-of-life pathology indicated that the incidence of neoplastic disease was not significantly different in the two groups of mice; however, it occurred in older aged PAPP-A KO compared with WT mice. Furthermore, PAPP-A KO mice were less likely to show degenerative changes of age. Scheduled pathologies at 78, 104, and 130 weeks of age indicated that WT mice, in general, had more degenerative changes and tumors earlier than PAPP-A KO mice. This was particularly true for abnormalities in heart, testes, brain, kidney, spleen, and thymus. In summary, the major contributors to the extended life span of PAPP-A KO mice are delayed occurrence of fatal neoplasias and decreased incidence of age-related degenerative changes. |
Links |
J:236957 – MGI References 20351075 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6;129 | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
40 - 59 |
||
| B6;129-Pappatm1Cac | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
5.3 - 33 |
||
| B6;129 | Blood vessel tumor | Blood vessel |
8.5 |
||
| B6;129-Pappatm1Cac | Blood vessel tumor | Blood vessel |
3.3 |
||
| B6;129 | Kidney cyst | Kidney |
0 - 6.9 |
||
| B6;129-Pappatm1Cac | Kidney cyst | Kidney |
0 |
||
| B6;129 | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 14 |
||
| B6;129-Pappatm1Cac | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 4.5 |
||
| B6;129 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 5.0 |
||
| B6;129-Pappatm1Cac | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 |
||
| B6;129 | Leukocyte lymphoma | Leukocyte |
0 - 31 |
||
| B6;129-Pappatm1Cac | Leukocyte lymphoma | Leukocyte |
0 - 14 |
||
| B6;129 | Leukocyte tumor | Leukocyte |
49 |
||
| B6;129-Pappatm1Cac | Leukocyte tumor | Leukocyte |
33 |
||
| B6;129 | Liver hepatocellular carcinoma | Liver |
8.5 |
||
| B6;129-Pappatm1Cac | Liver hepatocellular carcinoma | Liver |
17 |
||
| B6;129 | Lung adenocarcinoma | Lung |
3.4 - 5.0 |
||
| B6;129-Pappatm1Cac | Lung adenocarcinoma | Lung |
4.5 - 5.3 |
||
| B6;129 | Lung adenoma | Lung |
10.3 - 20 |
||
| B6;129-Pappatm1Cac | Lung adenoma | Lung |
4.5 - 10.5 |
||
| B6;129 | Lung carcinoma | Lung |
17 |
||
| B6;129-Pappatm1Cac | Lung carcinoma | Lung |
23 |
||
| B6;129 | Lung hyperplasia | Lung |
0 - 6.9 |
||
| B6;129-Pappatm1Cac | Lung hyperplasia | Lung |
0 - 4.5 |
||
| B6;129 | Mammary gland adenocarcinoma | Mammary gland |
observed |
||
| B6;129-Pappatm1Cac | Mammary gland adenocarcinoma | Mammary gland |
0 |
||
| B6;129 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 - 6.7 |
||
| B6;129-Pappatm1Cac | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
| B6;129 | Ovary cyst - epithelial | Ovary |
30 - 33 |
||
| B6;129-Pappatm1Cac | Ovary cyst - epithelial | Ovary |
9.1 - 10 |
||
| B6;129 | Pancreas - Islet of Langerhans hyperplasia | Pancreas - Islet of Langerhans |
0 - 11 |
||
| B6;129-Pappatm1Cac | Pancreas - Islet of Langerhans hyperplasia | Pancreas - Islet of Langerhans |
0 |
||
| B6;129 | Peritoneum - Ovarian bursa cyst | Peritoneum - Ovarian bursa |
6.7 - 10 |
||
| B6;129-Pappatm1Cac | Peritoneum - Ovarian bursa cyst | Peritoneum - Ovarian bursa |
0 - 9.1 |
||
| B6;129 | Pituitary gland - Pars distalis hyperplasia - focal | Pituitary gland - Pars distalis |
5.6 |
||
| B6;129-Pappatm1Cac | Pituitary gland - Pars distalis hyperplasia - focal | Pituitary gland - Pars distalis |
0 |
||
| B6;129 | Pituitary gland adenoma | Pituitary gland |
5.6 |
||
| B6;129-Pappatm1Cac | Pituitary gland adenoma | Pituitary gland |
0 |
||
| B6;129 | Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) |
0 - 10 |
||
| B6;129-Pappatm1Cac | Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) |
0 |
||
| B6;129 | Thyroid gland - Follicular cell hyperplasia | Thyroid gland - Follicular cell |
5.0 - 7.7 |
||
| B6;129-Pappatm1Cac | Thyroid gland - Follicular cell hyperplasia | Thyroid gland - Follicular cell |
0 |
||
| B6;129 | Thyroid gland cyst | Thyroid gland |
0 - 3.8 |
||
| B6;129-Pappatm1Cac | Thyroid gland cyst | Thyroid gland |
0 |
||
| B6;129 | Uterus - Endometrium - Stroma tumor | Uterus - Endometrium - Stroma |
observed |
||
| B6;129-Pappatm1Cac | Uterus - Endometrium - Stroma tumor | Uterus - Endometrium - Stroma |
0 |
||
| B6;129 | Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium |
70 - 87 |
||
| B6;129-Pappatm1Cac | Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium |
50 - 83 |
||
| B6;129 | (Unspecified organ) neoplasia | (Unspecified organ) |
high |
||
| B6;129-Pappatm1Cac | (Unspecified organ) neoplasia | (Unspecified organ) |
high |