Reference SummaryBomhard E, Exp Toxicol Pathol 1993 Oct;45(5-6):269-89

Title

Frequency of spontaneous tumours in NMRI mice in 21-month studies.

Authors

Bomhard E

Journal

Exp Toxicol Pathol

Volume

Issue

5-6

Year

1993

Pages

269-89

Abstract

Tumours occurring in 900 male and 900 female mice of the strain NMRI (BOR: NMRI (SPF Han), breeder: Winkelmann, Borchen) employed as control groups in 18 different studies lasting for 21 months on average (study No. 8 for 20 months, study No. 5 for 24 months) were compiled on the basis of histopathology reports. 883 male and 874 female mice were evaluated. The remaining animals were unavailable due to autolysis. A total of 1522 tumours (689 in males, 833 in females) were seen in 1061 mice (493 males, 568 females), 830 of which were classified as malignant (318 in males, 512 in females). About 70% of all primary tumours were located in the haemolymophoreticular tissue, lungs, ovaries, adrenals and uterus. Average incidences of primary tumours found in the following organs were: haemolymphoreticular tissue 22.9%, lungs 21.6%, ovaries 12.1%, adrenals 6.9%, uterus 6.6%, liver 4.4%, Harderian gland 4.4%, pituitary 3.5%, mamma 3.3% and various other organs with a tumour frequency below 3%. Male mice exhibited markedly more tumours of the lungs, adrenals, liver and Harderian glands, while tumours of the haemolymphoreticular tissue and pituitary were predominant in females. A comparison of these data with those from preceding two-year or life-span studies using NMRI mice from other breeders revealed a certain increase in primary tumours of the adrenals, Harderian glands as well as pituitary. This result could be due to more frequent examinations.

Links

J:237404 – MGI References
8312710 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
NMRI	These mice were control groups in 18 different studies performed between July 1981 and August 1988.

Models
Strain	Model Name	Organ Affected	Frequency
NMRI	Adipose tissue lipoma	Peritoneum - Mesentery	0 - observed
NMRI	Adipose tissue liposarcoma	Muscle - Striated - Skeletal	0 - 0.1
NMRI	Adrenal gland - Cortex adenocarcinoma	Adrenal gland - Cortex	0.3 - 0.6
NMRI	Adrenal gland - Cortex adenoma	Adrenal gland - Cortex	1.3 - 8.6
NMRI	Adrenal gland - Medulla pheochromocytoma - benign	Adrenal gland - Medulla	1.3 - 1.7
NMRI	Adrenal gland - Medulla pheochromocytoma - malignant	Adrenal gland - Medulla	0 - 0.2
NMRI	Adrenal gland tumor	Adrenal gland	2.9 - 11.1
NMRI	Blood vessel hemangioma	Blood vessel	1.1
NMRI	Blood vessel hemangiosarcoma	Blood vessel	1.4 - 1.5
NMRI	Blood vessel tumor	Blood vessel	2.5 - 2.6
NMRI	Bone - Femur osteosarcoma	Bone - Femur	0 - 0.3
NMRI	Bone osteosarcoma	Skin	0 - 0.1
NMRI	Bone osteosarcoma	Tail	0 - observed
NMRI	Bone osteosarcoma	Intestine - Small Intestine	0 - 0.1
NMRI	Bone osteosarcoma	Muscle - Striated - Skeletal	0 - 0.3
NMRI	CNS - Brain meningioma	CNS - Brain	0 - 0.1
NMRI	Connective tissue - Fibroblast fibroma	Tail	observed
NMRI	Connective tissue - Fibroblast fibroma	Muscle - Striated - Skeletal	0 - 0.1
NMRI	Connective tissue - Fibroblast fibrosarcoma	Skin	0.3
NMRI	Connective tissue - Fibroblast fibrosarcoma	Tail	0 - observed
NMRI	Connective tissue - Fibroblast fibrosarcoma	Epididymis	0.1
NMRI	Connective tissue - Fibroblast fibrosarcoma	Ear - Outer ear	0 - observed
NMRI	Connective tissue - Fibroblast fibrosarcoma	Connective tissue - Fibroblast	0 - observed
NMRI	Epididymis tumor - granular cell - benign	Epididymis	0.1
NMRI	Eye - Harderian gland adenocarcinoma	Eye - Harderian gland	0.2 - 0.3
NMRI	Eye - Harderian gland adenoma	Eye - Harderian gland	2.7 - 7.0
NMRI	Eye - Harderian gland tumor	Eye - Harderian gland	2.7 - 6.0
NMRI	Intestine - Large Intestine polyp	Intestine - Large Intestine	0 - 0.1
NMRI	Intestine - Small Intestine polyp - adenomatous	Intestine - Small Intestine	0 - 0.1
NMRI	Kidney adenoma	Kidney	0 - 0.3
NMRI	Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Salivary gland	0 - 0.1
NMRI	Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Leukocyte - Monocyte - Macrophage - Histiocyte	0.1 - 0.5
NMRI	Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant	Leukocyte - Monocyte - Macrophage - Histiocyte	0 - observed
NMRI	Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor - malignant	Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell	0 - 0.1
NMRI	Leukocyte leukemia	Leukocyte	0 - 0.8
NMRI	Leukocyte lymphoma	Leukocyte	9.4 - 35.2
NMRI	Liver hepatocellular adenoma	Liver	0.7 - 4.2
NMRI	Liver hepatocellular carcinoma	Liver	0.6 - 3.1
NMRI	Liver tumor	Liver	1.5 - 7.3
NMRI	Lung adenoma	Lung	7.7 - 14.1
NMRI	Lung carcinoma	Lung	8.0 - 13.7
NMRI	Lung tumor	Lung	15.6 - 27.6
NMRI	Mammary gland adenoacanthoma	Mammary gland	0 - 0.6
NMRI	Mammary gland adenoma	Mammary gland	0 - 0.3
NMRI	Mammary gland carcinoma	Mammary gland	0 - 3.1
NMRI	Mammary gland carcinosarcoma	Mammary gland	0 - 0.1
NMRI	Mammary gland tumor	Mammary gland	3.3
NMRI	Mesodermal cell/mesoblast sarcoma	Skin	0.1 - 0.5
NMRI	Mesodermal cell/mesoblast sarcoma	Subcutis	0 - observed
NMRI	Mesodermal cell/mesoblast sarcoma	Tail	0 - observed
NMRI	Mesodermal cell/mesoblast sarcoma	Liver	0 - 0.2
NMRI	Mesodermal cell/mesoblast sarcoma	Epididymis	0.1
NMRI	Mesodermal cell/mesoblast sarcoma	Uterus - Endometrium	0.3
NMRI	Mesodermal cell/mesoblast sarcoma	Vagina	0.5
NMRI	Mesodermal cell/mesoblast sarcoma	Peritoneum - Mesentery	0 - observed
NMRI	Mesodermal cell/mesoblast sarcoma	Serosa - Pelvic cavity	0 - observed
NMRI	Mesodermal cell/mesoblast sarcoma - pleomorphic	Skin	0 - 0.3
NMRI	Mesothelium mesothelioma - malignant	Mediastinum	0 - observed
NMRI	Mesothelium mesothelioma - malignant	Peritoneum - Mesentery	0 - observed
NMRI	Muscle - Smooth leiomyoma	Intestine - Large Intestine	0 - 0.1
NMRI	Muscle - Smooth leiomyoma	Epididymis	0.1
NMRI	Muscle - Smooth leiomyoma	Uterus	0.9
NMRI	Muscle - Smooth leiomyoma	Vagina	0.5
NMRI	Muscle - Smooth leiomyosarcoma	Intestine - Large Intestine	0 - 0.1
NMRI	Muscle - Smooth leiomyosarcoma	Seminal vesicle	0.1
NMRI	Muscle - Smooth leiomyosarcoma	Uterus	0.8
NMRI	Oral cavity papilloma	Oral cavity	0 - observed
NMRI	Ovary - Interstitial cell tumor - benign	Ovary - Interstitial cell	0.1
NMRI	Ovary - Luteal cell tumor - benign	Ovary - Luteal cell	0.2
NMRI	Ovary - Sertoli cell tumor - benign	Ovary - Sertoli cell	0.2
NMRI	Ovary adenoma	Ovary	0.1
NMRI	Ovary adenoma - papillary	Ovary	0.6
NMRI	Ovary adenoma - tubular	Ovary	1.0
NMRI	Ovary luteoma	Ovary	1.7
NMRI	Ovary tumor	Ovary	12.1
NMRI	Ovary tumor - granulosa-theca cell - benign	Ovary	7.0
NMRI	Ovary tumor - granulosa-theca cell - malignant	Ovary	1.0
NMRI	Oviduct carcinoma	Oviduct	observed
NMRI	PNS - Schwann cell schwannoma - malignant	Skin	0 - 0.1
NMRI	Pancreas - Islet of Langerhans adenoma	Pancreas - Islet of Langerhans	0 - 0.5
NMRI	Parathyroid gland adenoma	Parathyroid gland	0 - 0.6
NMRI	Pituitary gland adenoma	Pituitary gland	0.9 - 6.5
NMRI	Preputial gland (male) cystadenoma	Preputial gland (male)	observed
NMRI	Prostate gland carcinoma	Prostate gland	0.2
NMRI	Seminal vesicle tumor - granular cell - benign	Seminal vesicle	0.1
NMRI	Skin - Epidermis - Basal cell carcinoma	Skin - Epidermis - Basal cell	0 - 0.1
NMRI	Skin papilloma	Skin	0 - 0.1
NMRI	Skin tumor	Skin	0.6 - 1.4
NMRI	Stomach adenocarcinoma	Stomach	0.2 - 0.7
NMRI	Stomach adenoma	Stomach	0.1 - 1.0
NMRI	Stomach carcinoma - spindle cell	Stomach	0 - 0.1
NMRI	Stomach papilloma	Stomach	0.1
NMRI	Stomach polyp - adenomatous	Stomach	0 - 0.1
NMRI	Stomach tumor	Stomach	0.5 - 2.0
NMRI	Subcutis carcinoma - basosquamous	Subcutis	0 - observed
NMRI	Testis - Leydig cell (Interstitial cell) tumor - benign	Testis - Leydig cell (Interstitial cell)	1.7
NMRI	Testis - Leydig cell (Interstitial cell) tumor - benign	Epididymis	0.1
NMRI	Testis - Leydig cell (Interstitial cell) tumor - malignant	Testis - Leydig cell (Interstitial cell)	0.5
NMRI	Testis - Rete testis adenoma	Testis - Rete testis	0.1
NMRI	Testis - Seminiferous tubules - Sertoli cell tumor - benign	Testis - Seminiferous tubules - Sertoli cell	0.2
NMRI	Testis adenoma - tubular	Testis	0.2
NMRI	Testis tumor	Testis	2.7
NMRI	Thymus thymoma - malignant	Thymus	0 - observed
NMRI	Thyroid gland - Follicular cell adenoma	Thyroid gland - Follicular cell	0 - 0.5
NMRI	Thyroid gland - Follicular cell carcinoma	Thyroid gland - Follicular cell	0 - 0.1
NMRI	Thyroid gland adenoma	Thyroid gland	0 - 0.1
NMRI	Thyroid gland carcinoma	Thyroid gland	0 - 0.1
NMRI	Thyroid gland cystadenoma - papillary	Thyroid gland	0.1
NMRI	Urinary bladder transitional cell carcinoma	Urinary bladder	0.1 - 0.3
NMRI	Urinary bladder tumor - benign	Urinary bladder	0 - 0.2
NMRI	Urinary bladder tumor - stromal - benign	Urinary bladder	0 - 0.1
NMRI	Uterus - Endometrium - Stroma polyp	Uterus - Endometrium - Stroma	1.7
NMRI	Uterus adenocarcinoma	Uterus	0.6
NMRI	Uterus adenoma	Uterus	0.2
NMRI	Uterus polyp - glandular	Uterus	0.2
NMRI	Uterus sarcoma - stromal	Uterus	1.3
NMRI	Uterus squamous cell carcinoma	Uterus	0.1
NMRI	Uterus tumor	Uterus	6.6
NMRI	Uterus tumor - benign	Uterus	0.3
NMRI	(Unspecified organ) reticulum cell sarcoma	(Unspecified organ)	0.1 - 0.2
NMRI	(Unspecified organ) tumor	(Unspecified organ)	9.7 - 65.0
NMRI	(Unspecified organ) tumor - benign	(Unspecified organ)	29.3 - 34.5
NMRI	(Unspecified organ) tumor - malignant	(Unspecified organ)	32.0 - 50.5