Reference SummaryNagasawa H, J Natl Cancer Inst 1976 Aug;57(2):425-30

Title

 Two-way selection of a stock of Swiss albino mice for mammary tumorigenesis: establishment of two new strains (SHN and SLN).

Authors

 Nagasawa H; Yanai R; Taniguchi H; Tokuzen R; Nakahara W

Journal

 J Natl Cancer Inst

Volume

 57

Issue

 2

Year

 1976

Pages

 425-30

Abstract

 Two mouse strains (SHN and SLN) with high and low incidences, respectively, of mammary tumors were established from the same basal stock of Swiss albino mice that were unrelated in origin to other mouse strains with mammary tumors. In the breeders, mammary tumor incidence and average age of the mice when they developed mammary tumors were 97.2 % and 6.6 months for SHN, and 5.57% and 10.1 months for SLN, respectively...

Links

 J:25446 – MGI References
187774 – National Library of Medicine/PubMed

Strain Notes

Strain Note
SHN The wild type allele of the Prl gene was reported to be expressed in an unspecified organ in virgin mice and was reported to be up-regulated in an unspecified organ in pregnant mice.
(SHN x SLN)F1-Mtv4a Carrier of MMTV via Mtv4.
SLN The wild type allele of the Prl gene was reported to be expressed in an unspecified organ in virgin mice and was reported to be up-regulated in an unspecified organ in pregnant mice.
Visual Summary Grid

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
SHN Mammary gland adenocarcinoma Mammary gland

88 - 97
SLN Mammary gland adenocarcinoma Mammary gland

10 - 56
(SHN x SLN)F1-Mtv4a Mammary gland adenocarcinoma Mammary gland

58
(SLN x SHN)F1-Mtv4a Mammary gland adenocarcinoma Mammary gland

6.7
SHN Mammary gland hyperplasia - alveolar Mammary gland

0 - 100
SLN Mammary gland hyperplasia - alveolar Mammary gland

0 - 11
(SHN x SLN)F1-Mtv4a Mammary gland hyperplasia - alveolar Mammary gland

observed
(SLN x SHN)F1-Mtv4a Mammary gland hyperplasia - alveolar Mammary gland

observed