Reference SummaryTamano S, Toxicol Pathol 1988;16(3):321-6

Title

 Spontaneous tumors in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice.

Authors

 Tamano S; Hagiwara A; Shibata MA; Kurata Y; Fukushima S; Ito N

Journal

 Toxicol Pathol

Volume

 16

Issue

 3

Year

 1988

Pages

 321-6

Abstract

 Spontaneous tumors in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls in carcinogenicity tests were recorded. In both sexes, the development of spontaneous tumors was age-related. In 244 male mice, the most common tumors were hyperplastic nodules of the liver, hepatocellular carcinomas, malignant lymphomas/leukemias, lung adenomas, and adenocarcinomas. In 246 female mice, the most common tumors were malignant lymphomas/leukemias, pituitary adenomas, neoplastic nodules of the liver, hepatocellular carcinomas, and lung adenomas. Hepatocellular carcinomas metastasized in 20.3% of the animals with these tumors. Few other tumors except malignant lymphomas and leukemias metastasized. Various tumors of other organs and/or tissues were found at low incidences.

Links

 J:26024 – MGI References
3194653 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6N x C3H/HeN)F1 Adipose tissue lipoma Peritoneal cavity

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Adipose tissue liposarcoma Peritoneal cavity

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0.4 - 1.2
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Blood vessel

4.5 - 6.1
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Blood vessel

2.5 - 3.7
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibroma (Unspecified organ)

0.4 - 2.5
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibrosarcoma Liver

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibrosarcoma (Unspecified organ)

0.8 - 2.9
(C57BL/6N x C3H/HeN)F1 Esophagus squamous cell carcinoma Esophagus

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Eye - Harderian gland adenoma Eye - Harderian gland

2.5 - 2.8
(C57BL/6N x C3H/HeN)F1 Forestomach squamous cell carcinoma Forestomach

0 - 0.8
(C57BL/6N x C3H/HeN)F1 Forestomach squamous cell papilloma Forestomach

0.4 - 0.8
(C57BL/6N x C3H/HeN)F1 Kidney transitional cell carcinoma Kidney

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Leukocyte tumor - malignant Leukocyte

14.3 - 23.6
(C57BL/6N x C3H/HeN)F1 Liver hepatocellular adenoma Liver

5.7 - 26.2
(C57BL/6N x C3H/HeN)F1 Liver hepatocellular carcinoma Liver

4.5 - 23.8
(C57BL/6N x C3H/HeN)F1 Liver lesion Liver

10.2 - 48.0
(C57BL/6N x C3H/HeN)F1 Lung adenocarcinoma Lung

2.0 - 4.9
(C57BL/6N x C3H/HeN)F1 Lung adenoma Lung

3.3 - 9.0
(C57BL/6N x C3H/HeN)F1 Mammary gland adenocarcinoma Mammary gland

0 - 1.2
(C57BL/6N x C3H/HeN)F1 Mammary gland fibroadenoma Mammary gland

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Uterus - Endometrium - Stroma

0.4
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma - unclassified Liver

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma - unclassified Uterus

0.8
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyoma Intestine - Large Intestine

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Intestine - Large Intestine

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Epididymis

0.4
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Muscle - Smooth

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Uterus

2.0
(C57BL/6N x C3H/HeN)F1 Neuroblast neuroblastoma Pancreas

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Nose - Nasal cavity adenocarcinoma Nose - Nasal cavity

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Ovary - Germ cell teratoma Ovary - Germ cell

0.4
(C57BL/6N x C3H/HeN)F1 Ovary adenoma Ovary

0.4
(C57BL/6N x C3H/HeN)F1 Ovary cystadenoma Ovary

1.2
(C57BL/6N x C3H/HeN)F1 Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0 - 1.2
(C57BL/6N x C3H/HeN)F1 Pituitary gland adenocarcinoma Pituitary gland

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Pituitary gland adenoma Pituitary gland

0.4 - 6.9
(C57BL/6N x C3H/HeN)F1 Pleural cavity tumor Pleural cavity

0
(C57BL/6N x C3H/HeN)F1 Skin gland - Sebaceous gland adenoma Skin gland - Sebaceous gland

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Testis - Germ cell seminoma Testis - Germ cell

0.4
(C57BL/6N x C3H/HeN)F1 Thyroid gland adenoma Thyroid gland

0.4 - 0.8
(C57BL/6N x C3H/HeN)F1 Tongue squamous cell carcinoma Tongue

0 - 0.4
(C57BL/6N x C3H/HeN)F1 Urinary bladder tumor Urinary bladder

0
(C57BL/6N x C3H/HeN)F1 Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma

0.4
(C57BL/6N x C3H/HeN)F1 Vagina adenocarcinoma Vagina

0.4
(C57BL/6N x C3H/HeN)F1 (Unspecified organ) histiocytoma - fibrous - malignant (Unspecified organ)

0 - 3.3
(C57BL/6N x C3H/HeN)F1 (Unspecified organ) tumor (Unspecified organ)

47.9 - 76.0