Reference SummaryToth B, Br J Cancer 1980;42():922-928

Title

 Tumorigenesis by N-n-propyl-N-Formyhydrazine in mice

Authors

 Toth B; Nagel D; Patil K

Journal

 Br J Cancer

Volume

 42

Issue

Year

 1980

Pages

 922-928

Abstract

 Continuous administration of 0.04% N-n-propyl-N-formylhydrazine (PFH) for life in drinking water to 6-week-old randomly bred Swiss mice induced tumours of the lungs, preputial glands, liver and gallbladder. The tumour incidences in these 4 tissues were 91, 22, 8 and 6%, whereas in the untreated controls they were 25, 0, 0.5 and 0.5%, respectively. The higher dose of 0.08% PFH, given under identical conditions, induced only tumours of the lungs, liver and gall bladder in low incidences, since the compound was too toxic for the mice. Histopathologically, the tumours were classified as adenomas and adenocarcinomas of the lungs, squamous-cell papillomas, and carcinomas and fibrosarcoma of preputial glands, benign hepatomas and liver-cell carcinoma, as well as adenomas and adenocarcinoma of the gall bladder. The investigation is part of our structure/activity relationship inquiry aimed at revealing the mechanism of action of the N-alkyl-N-formylhydrazine series of chemicals.

Links

 J:269928 – MGI References

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
Swiss Adrenal gland - Cortex adenoma Adrenal gland - Cortex

1
Swiss Clitoral gland squamous cell carcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Clitoral gland

2 - 4
Swiss Connective tissue - Fibroblast fibroma Mammary gland

1
Swiss Connective tissue - Fibroblast fibrosarcoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Subcutis

2
Swiss Connective tissue - Fibroblast fibrosarcoma Subcutis

1 - 2
Swiss Connective tissue - Fibroblast fibrosarcoma Lymph node - Submandibular

1
Swiss Connective tissue - Fibroblast fibrosarcoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Preputial gland (male)

2
Swiss Forestomach papilloma Forestomach

4
Swiss Forestomach squamous cell carcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Forestomach

2
Swiss Gallbladder adenocarcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Gallbladder

0
Swiss Gallbladder adenoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Gallbladder

2 - 10
Swiss Gallbladder tumor
  • N-n-propyl-N-formylhydrazine (PFH)
 Gallbladder

2 - 10
Swiss Gallbladder tumor Gallbladder

0 - 1
Swiss Intestine - Large Intestine - Colon adenoma - polypoid Intestine - Large Intestine - Colon

1
Swiss Intestine - Small Intestine - Duodenum adenocarcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Intestine - Small Intestine - Duodenum

2
Swiss Kidney adenocarcinoma Kidney

1
Swiss Leukocyte - Lymphocyte lymphoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Leukocyte - Lymphocyte

2 - 6
Swiss Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

18
Swiss Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1
Swiss Liver - Bile duct cholangiocarcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Liver - Bile duct

2
Swiss Liver - Bile duct lymphoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Liver - Bile duct

2
Swiss Liver carcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Liver

2
Swiss Liver hepatoma - benign
  • N-n-propyl-N-formylhydrazine (PFH)
 Liver

4 - 12
Swiss Liver tumor
  • N-n-propyl-N-formylhydrazine (PFH)
 Liver

0 - 12
Swiss Liver tumor Liver

0 - 1
Swiss Lung adenocarcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Lung

0 - 62
Swiss Lung adenoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Lung

14 - 98
Swiss Lung tumor
  • N-n-propyl-N-formylhydrazine (PFH)
 Lung

14 - 98
Swiss Lung tumor Lung

8 - 26
Swiss Lymph node - Submandibular adenocarcinoma Lymph node - Submandibular

1
Swiss Mammary gland adenocarcinoma Mammary gland

2
Swiss Mesodermal cell/mesoblast lymphoma Retroperitoneum

1
Swiss Mesodermal cell/mesoblast myxosarcoma Uterus

1
Swiss Ovary - Granulosa cell tumor - granulosa cell
  • N-n-propyl-N-formylhydrazine (PFH)
 Ovary - Granulosa cell

2
Swiss Ovary adenocarcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Ovary

2
Swiss Preputial gland (male) squamous cell carcinoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Preputial gland (male)

2 - 18
Swiss Preputial gland (male) squamous cell papilloma
  • N-n-propyl-N-formylhydrazine (PFH)
 Preputial gland (male)

4
Swiss Preputial gland (male) tumor
  • N-n-propyl-N-formylhydrazine (PFH)
 Preputial gland (male)

2 - 22
Swiss Preputial gland (male) tumor Preputial gland (male)

0
Swiss Thyroid gland adenoma Thyroid gland

1
Swiss (Unspecified organ) angioma
  • N-n-propyl-N-formylhydrazine (PFH)
 Spleen

4
Swiss (Unspecified organ) angioma Liver

6 - 9
Swiss (Unspecified organ) angioma Uterus

6
Swiss (Unspecified organ) angioma Ovary

6
Swiss (Unspecified organ) angiosarcoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Spleen

2
Swiss (Unspecified organ) angiosarcoma
  • N-n-propyl-N-formylhydrazine (PFH)
 Liver

2
Swiss (Unspecified organ) angiosarcoma Liver

4
Swiss (Unspecified organ) tumor - granulosa cell (Unspecified organ)

1