Reference SummaryDove WF, Cancer Res 1997 Mar 1;57(5):812-4
Title |
Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. |
Authors |
Dove WF; Clipson L; Gould KA; Luongo C; Marshall DJ; Moser AR; Newton MA; Jacoby RF |
Journal |
Cancer Res |
Volume |
57 |
Issue |
5 |
Year |
1997 |
Pages |
812-4 |
Abstract |
We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6- Apc(Min)/+ mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9; P < 0.003), but there were no significant differences in the rest of the intestinal tract. We conclude that microbial status does not strongly alter the adenoma phenotype in this mouse model of familial adenomatous polyposis. In parallel, we have found that C57BL/6-Apc(Min)/+ mice mutated at the beige locus. Which controls natural killer activity, are also unaltered in adenoma multiplicity. |
Links |
J:38777 – MGI References 9041176 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J/+ | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J/+ | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |
||
| C57BL/6J-ApcMin/+ Lystbg-J/+ | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |