Reference SummaryTakeda T, Exp Gerontol 1997 Jan-Apr;32(1-2):117-27

Title

 Pathobiology of the senescence-accelerated mouse (SAM).

Authors

 Takeda T; Matsushita T; Kurozumi M; Takemura K; Higuchi K; Hosokawa M

Journal

 Exp Gerontol

Volume

 32

Issue

 1-2

Year

 1997

Pages

 117-27

Abstract

 Routine postmortem examinations and the pathobiological features revealed by systematically designed studies have shown several pathologic phenotypes that are often characteristic enough to differentiate among the various SAM strains: senile amyloidosis in SAMP1, -P2, -P7, -P9, -P10, and -P11; secondary amyloidosis in SAMP2 and -P6; contracted kidney in SAMP1, -P2, -P10, and -P11; immunoblastic lymphoma in SAMR1 and -R4; histiocytic sarcoma in SAMR1 and -R4; ovarian cysts in SAMR1; impaired immune response in SAMP1, -P2, and -P8; hyperinflation of the lungs in SAMP1; hearing impairment in SAMP1; degenerative temporomandibular joint disease in SAMP3; senile osteoporosis in SAMP6; deficits in learning and memory in SAMP8 and -P10; emotional disorders in SAMP8 and -P10; cataracts in SAMP9; and brain atrophy in SAMP10. These are all age-associated pathologies, the incidence and severity of which increase with advancing age. The SAM model in which these pathobiological features have been carefully monitored will be a valuable tool in the clarification of the pathogenic mechanisms of age-associated pathologies and in the research for effective methods to modulate or ameliorate these pathologies.

Links

 J:38979 – MGI References
9088909 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
SAMP1 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

4.8
SAMP2 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

2.6
SAMP2 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

1.3
SAMP3 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

6.1
SAMP6 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

0
SAMP7 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

56
SAMP7 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

1.1
SAMP8 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

24
SAMP8 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

2.2
SAMP9 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

43
SAMP10 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

1.0
SAMP11 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

0
SAMR1 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

1.3
SAMR1 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

1.3
SAMR4 Leukocyte - Lymphoblast leukemia - lymphoblastic Thymus

1.9
SAMR4 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

1.9
SAMR5 Leukocyte - Lymphoblast leukemia - lymphoblastic Leukocyte - Lymphoblast

1.3
SAMP1 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP2 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP3 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP6 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP7 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

1.1
SAMP8 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP9 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP10 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP11 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMR1 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

1.3
SAMR4 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

1.9
SAMR5 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell leukemia Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

0
SAMP1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0.9 - 1.6
SAMP2 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMP3 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMP6 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMP7 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0.4 - 1.1
SAMP8 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMP9 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMP10 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMP11 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0
SAMR1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

4.6 - 19
SAMR4 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

6.5 - 15
SAMR5 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

5.2 - 9.3
SAMP1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1.6
SAMP2 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMP3 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMP6 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMP7 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1.1
SAMP8 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMP9 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMP10 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1.0
SAMP11 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMR1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

3.9
SAMR4 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1.9
SAMR5 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
SAMP1 Leukocyte leukemia - immunoblastic Leukocyte

1.6
SAMP2 Leukocyte leukemia - immunoblastic Leukocyte

0
SAMP3 Leukocyte leukemia - immunoblastic Leukocyte

1.5
SAMP6 Leukocyte leukemia - immunoblastic Leukocyte

0
SAMP7 Leukocyte leukemia - immunoblastic Leukocyte

2.3
SAMP8 Leukocyte leukemia - immunoblastic Leukocyte

4.3
SAMP9 Leukocyte leukemia - immunoblastic Leukocyte

0
SAMP10 Leukocyte leukemia - immunoblastic Leukocyte

2.9
SAMP11 Leukocyte leukemia - immunoblastic Leukocyte

0
SAMR1 Leukocyte leukemia - immunoblastic Leukocyte

14
SAMR4 Leukocyte leukemia - immunoblastic Leukocyte

15
SAMR5 Leukocyte leukemia - immunoblastic Leukocyte

1.3
SAMP1 Leukocyte lymphohematopoietic neoplasm Leukocyte

2.7
SAMP2 Leukocyte lymphohematopoietic neoplasm Leukocyte

1.5
SAMP3 Leukocyte lymphohematopoietic neoplasm Leukocyte

6.2
SAMP6 Leukocyte lymphohematopoietic neoplasm Leukocyte

0
SAMP7 Leukocyte lymphohematopoietic neoplasm Leukocyte

38
SAMP8 Leukocyte lymphohematopoietic neoplasm Leukocyte

23
SAMP9 Leukocyte lymphohematopoietic neoplasm Leukocyte

47
SAMP10 Leukocyte lymphohematopoietic neoplasm Leukocyte

1.5
SAMP11 Leukocyte lymphohematopoietic neoplasm Leukocyte

0
SAMR1 Leukocyte lymphohematopoietic neoplasm Leukocyte

5.5
SAMR4 Leukocyte lymphohematopoietic neoplasm Leukocyte

10
SAMR5 Leukocyte lymphohematopoietic neoplasm Leukocyte

2.6
SAMP8 Leukocyte lymphoma Leukocyte

2.2
SAMR4 Leukocyte lymphoma Leukocyte

1.9
SAMP1 Ovary cyst Ovary

0
SAMP2 Ovary cyst Ovary

0
SAMP3 Ovary cyst Ovary

2.5
SAMP6 Ovary cyst Ovary

0
SAMP7 Ovary cyst Ovary

1.8
SAMP8 Ovary cyst Ovary

0
SAMP9 Ovary cyst Ovary

0
SAMP10 Ovary cyst Ovary

2.9
SAMP11 Ovary cyst Ovary

0
SAMR1 Ovary cyst Ovary

46
SAMR4 Ovary cyst Ovary

13
SAMR5 Ovary cyst Ovary

13
SAMP1 (Unspecified organ) tumor (Unspecified organ)

1.8 - 4.8
SAMP7 (Unspecified organ) tumor (Unspecified organ)

0.8 - 1.1
SAMP9 (Unspecified organ) tumor (Unspecified organ)

2.9
SAMP10 (Unspecified organ) tumor (Unspecified organ)

0.5 - 1.0
SAMR1 (Unspecified organ) tumor (Unspecified organ)

3.0 - 3.9
SAMR4 (Unspecified organ) tumor (Unspecified organ)

2.2 - 3.8
SAMR5 (Unspecified organ) tumor (Unspecified organ)

2.6 - 4
SAMP1 (Unspecified organ) tumor - benign (Unspecified organ)

3.2
SAMP2 (Unspecified organ) tumor - benign (Unspecified organ)

1.3
SAMP3 (Unspecified organ) tumor - benign (Unspecified organ)

3.0
SAMP6 (Unspecified organ) tumor - benign (Unspecified organ)

2.0
SAMP7 (Unspecified organ) tumor - benign (Unspecified organ)

1.1
SAMP8 (Unspecified organ) tumor - benign (Unspecified organ)

2.2
SAMP9 (Unspecified organ) tumor - benign (Unspecified organ)

5.7
SAMP10 (Unspecified organ) tumor - benign (Unspecified organ)

2.9
SAMR4 (Unspecified organ) tumor - benign (Unspecified organ)

1.9
SAMR5 (Unspecified organ) tumor - benign (Unspecified organ)

8