Reference SummaryTwentyman PR, J Natl Cancer Inst 1980 Mar;64(3):595-604
Title |
A new mouse tumor model system (RIF-1) for comparison of end-point studies. |
Authors |
Twentyman PR; Brown JM; Gray JW; Franko AJ; Scoles MA; Kallman RF |
Journal |
J Natl Cancer Inst |
Volume |
64 |
Issue |
3 |
Year |
1980 |
Pages |
595-604 |
Abstract |
A new tumor model system (RIF-1) was developed that is very suitable for studies in which clonogenic survival is compared with growth delay and control probability following various forms of treatment. The tumor was a radiation-induced sarcoma in the inbred female C3H/Km mouse. It had a low median tumor dose, had a satisfactory plating efficiency direct from in vivo to in vitro, was nonimmunogenic or minimally immunogenic, and metastasized only at a relatively advanced stage of growth. The cell line grew either as a monolayer on plastic dishes, as tumor spheroids in spinner culture, as lung nodules following injection of a single-cell suspension into the tail veins of syngeneic mice, or as a solid tumor. Both diploid and tetraploid clonogenic cells were found in monolayer cultures of the RIF-1 line. |
Links |
J:46449 – MGI References 6928244 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C3H/Km | (Unspecified organ) tumor |
|
(Unspecified organ) |
19 |