Reference SummaryBenigni R, Mutat Res 1998 Oct 12;421(1):93-107

Title

 Profiles of chemically-induced tumors in rodents: quantitative relationships.

Authors

 Benigni R; Pino A

Journal

 Mutat Res

Volume

 421

Issue

 1

Year

 1998

Pages

 93-107

Abstract

 The rodent carcinogenicity bioassay has been used for several decades for evaluating hundreds of chemicals, with the two aims of better understanding the etiologies of cancer, and of assessing the hazard posed by environmental and industrial chemicals. This has generated an enormous wealth of data and information on the phenomenon of chemical carcinogenicity. However, this information cannot be appreciated easily, since too many details may obscure the general trends present in the data; on the contrary, the use of computerized data analysis techniques suitable for the exploration of large databases makes its investigation much more fruitful, and its results more reliable. For this work, we collected a database of 536 rodent carcinogens, and we investigated the profiles of tumors (target organs) induced in the four experimental systems which are usually employed (rat and mouse, male and female). The analysis was performed with an Artificial Neural Network called Kohonen Self-Organizing Map, which is a computer-intensive method aimed at making the relevant information emerge automatically from the data itself. The analysis generated a global view, as well as a quantitative measure of the associations among the individual tumor types, and among the tumor profiles induced by the chemicals. In the complex interplay between the organ and species specificity of tumor induction, the species specificity generally overcame organ specificity, except for a few tumors (namely Lymphatic System, Brain, Forestomach, Stomach and Thyroid Gland). Moreover, the species specificity was remarkably stronger than the trans-species sex specificity. For three chemical classes (Aromatic Amines, Electrophilic/Alkylating Agents, Nitroarenes) most represented in the database, we investigated the hypothesis that a single mechanism of interaction with DNA would produce one, or a few very similar tumor profiles. Our analysis pointed out that no obvious association exists between chemical/mode of action class, and tumor profile. On the contrary, none of these classes induces a single tumor or pattern of tumors, but rather it appears that each class produces tumors at a wide range of sites. This suggests that an important determinant of the differences in tumor profile are the events that surround the ultimate mechanism of interaction with DNA. Copyright 1998 Elsevier Science B.V.

Links

 J:50083 – MGI References
9748520 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Adrenal gland

observed
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Adrenal gland

observed
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • chlorinated paraffins
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • 4-aminobiphenyl
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • cobalt sulfate heptahydrate
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • agar
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • cytembena
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • allyl isothiocyanate
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • acrylonitrile
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Adrenal gland

0
(C57BL/6 x C3H)F1 Adrenal gland tumor
  • 2-amino-4-nitrophenol
 Adrenal gland

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Blood vessel

observed
(C57BL/6 x C3H)F1 Blood vessel tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Blood vessel

observed
(C57BL/6 x C3H)F1 Blood vessel tumor
  • chlorinated paraffins
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • 4-aminobiphenyl
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • cobalt sulfate heptahydrate
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • agar
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • cytembena
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • allyl isothiocyanate
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • acrylonitrile
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Blood vessel

0
(C57BL/6 x C3H)F1 Blood vessel tumor
  • 2-amino-4-nitrophenol
 Blood vessel

0
(C57BL/6 x C3H)F1 Bone tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • chlorinated paraffins
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • 4-aminobiphenyl
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • cobalt sulfate heptahydrate
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • agar
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • cytembena
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • allyl isothiocyanate
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • acrylonitrile
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Bone

0
(C57BL/6 x C3H)F1 Bone tumor
  • 2-amino-4-nitrophenol
 Bone

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 CNS - Brain

observed
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 CNS - Brain

observed
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • chlorinated paraffins
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • 4-aminobiphenyl
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • cobalt sulfate heptahydrate
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • agar
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • cytembena
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • allyl isothiocyanate
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • acrylonitrile
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 CNS - Brain

0
(C57BL/6 x C3H)F1 CNS - Brain tumor
  • 2-amino-4-nitrophenol
 CNS - Brain

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Clitoral gland

observed
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • chlorinated paraffins
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • 4-aminobiphenyl
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • cobalt sulfate heptahydrate
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • agar
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • cytembena
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • allyl isothiocyanate
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • acrylonitrile
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Clitoral gland

0
(C57BL/6 x C3H)F1 Clitoral gland tumor
  • 2-amino-4-nitrophenol
 Clitoral gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Ear - Zymbal gland

observed
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Ear - Zymbal gland

observed
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • chlorinated paraffins
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • 4-aminobiphenyl
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • cobalt sulfate heptahydrate
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • agar
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • cytembena
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • allyl isothiocyanate
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • acrylonitrile
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear - Zymbal gland tumor
  • 2-amino-4-nitrophenol
 Ear - Zymbal gland

0
(C57BL/6 x C3H)F1 Ear tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Ear

0 - observed
(C57BL/6 x C3H)F1 Ear tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Ear

0 - observed
(C57BL/6 x C3H)F1 Ear tumor
  • chlorinated paraffins
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • 4-aminobiphenyl
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • cobalt sulfate heptahydrate
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • agar
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • cytembena
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • allyl isothiocyanate
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • acrylonitrile
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Ear

0
(C57BL/6 x C3H)F1 Ear tumor
  • 2-amino-4-nitrophenol
 Ear

0
(C57BL/6 x C3H)F1 Esophagus tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Esophagus

0
(C57BL/6 x C3H)F1 Esophagus tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Esophagus

observed
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Eye - Harderian gland

observed
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Eye - Harderian gland

observed
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • chlorinated paraffins
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • 4-aminobiphenyl
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • cobalt sulfate heptahydrate
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • agar
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • cytembena
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • allyl isothiocyanate
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • acrylonitrile
 Eye - Harderian gland

0 - observed
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Eye - Harderian gland tumor
  • 2-amino-4-nitrophenol
 Eye - Harderian gland

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • chlorinated paraffins
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 4-aminobiphenyl
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • cobalt sulfate heptahydrate
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • agar
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • cytembena
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • allyl isothiocyanate
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • acrylonitrile
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-amino-4-nitrophenol
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Acetaldeyde methylformylhydrazine
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Acetone[4-(5nitro2furyl)-2-thyazolyl]-hydrazone
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1-Acetoxysafrole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Amino-4-(5-nitro-2-furyl)-thiazole
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Amino-3,4-dimethylimidazo(4,5-f )-quinoline
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Amino-5-(5-nitro-2-furyl)1,3,4-thiadiazole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1-Amino-2,4-dibromoantraquinone
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Amino-3-methylimidazo(4,5-f )-quinoline
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Amino-5(5-nitro-2-furyl)1,3,4-oxadiazole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1-Amyl-1-nitrosourea
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Benzaldehyde
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • benzofuran
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Benzyl acetate
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Benzyl chloride
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2,2-bis(Bromomethyl)-1,3-propanediol
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Bromoethanol
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Butyl-N-nitrosourea
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Butylated hydroxyanisole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1,1-di-n-Butylhydrazine
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Captafol
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Carbazol
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 3-Chloro-2-methylpropene
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 4-Chloro-o-phenylenediamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • chloroprene
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Chloropropanal
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1-Chloropropene
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Ci Direct Blue 218
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Cupferron
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1,1-Diallylhydrazine
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2,3-dibromo-1-propanol
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1,2-dichloroethane
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Dichlorvos
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Diglycidyl resorcinol ether
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • dimethyl hydrogen phosphite
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Dimethylvinyl chloride
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Dinitrosopiperazine
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Ethyl acrylate
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Formic acid 2-[4(5-nitro-2-furyl)-2- 1 1 thiazolyl]hydrazide
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Furan-2-carbaldehyde (Furfural)
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • glycidol
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Hydrazino-4-(p-nitrophenyl)-thiazole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-hydroxy-2-acetylaminofluorene
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1'-Hydroxysafrole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Iodinated glycerol
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1-Methyl-1,4-dihydro-7-[2-(5-nitrofutyl)vinyl]-4-oxo-1,8-naphthyridine-3-carboxylate,potassium
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Mercuric chloride
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-methyl-N-nitrosobenzamide
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2-Methyl-1-nitroantraquinone
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Methylnitrosocianamide
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol- 1 1 2-yl] acetamide
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 4-(5-nitro-2-furyl)-thiazole
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 8-Nitroquinoline
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Nitroso-N-methyl-N-(2-phenyl)ethylamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitroso-N-methyl-N-dodecylamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitroso-N-methyldecylamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Nitroso-baygon
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitroso-2,3-dihydroxypropyl-2-hydroxypropylamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1-Nitroso-3,5-dimethyl-4-benzoylpiperazine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Nitroso-2,3-dihydroxypropyl-2-oxopropylamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Nitrosoamylurethane
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitrosobenzothiazuron
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Nitrosodibutylamine
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitrosodiethylamine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitrosoephedrine
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Nitrosoethylurethane
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • N-Nitrosopiperidine
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Pivalolactone
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • Propiolactone beta
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • Styrene oxide
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • sulfallate
 Forestomach

0
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1,3-dichloropropene (telone II)
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 1,2,3-Trichloropropane
 Forestomach

observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • 2,2,2-Trifluoro-N- 1[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Forestomach tumor
  • trifluralin
 Forestomach

0 - observed
(C57BL/6 x C3H)F1 Gallbladder tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Gallbladder

0
(C57BL/6 x C3H)F1 Gallbladder tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Gallbladder

observed
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Intestine - Large Intestine - Colon

observed
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Intestine - Large Intestine - Colon

observed
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • chlorinated paraffins
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • 4-aminobiphenyl
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • cobalt sulfate heptahydrate
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • agar
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • cytembena
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • allyl isothiocyanate
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • acrylonitrile
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine - Large Intestine - Colon tumor
  • 2-amino-4-nitrophenol
 Intestine - Large Intestine - Colon

0
(C57BL/6 x C3H)F1 Intestine tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Intestine

observed
(C57BL/6 x C3H)F1 Intestine tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Intestine

observed
(C57BL/6 x C3H)F1 Intestine tumor
  • chlorinated paraffins
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • 4-aminobiphenyl
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • cobalt sulfate heptahydrate
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • agar
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • cytembena
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • allyl isothiocyanate
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • acrylonitrile
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Intestine

0
(C57BL/6 x C3H)F1 Intestine tumor
  • 2-amino-4-nitrophenol
 Intestine

0
(C57BL/6 x C3H)F1 Kidney tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Kidney

observed
(C57BL/6 x C3H)F1 Kidney tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Kidney

observed
(C57BL/6 x C3H)F1 Kidney tumor
  • chlorinated paraffins
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • 4-aminobiphenyl
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • cobalt sulfate heptahydrate
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • agar
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • cytembena
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • allyl isothiocyanate
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • acrylonitrile
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Kidney

0
(C57BL/6 x C3H)F1 Kidney tumor
  • 2-amino-4-nitrophenol
 Kidney

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • chlorinated paraffins
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • 4-aminobiphenyl
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • cobalt sulfate heptahydrate
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • agar
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • cytembena
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • allyl isothiocyanate
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • acrylonitrile
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct cholangioma
  • 2-amino-4-nitrophenol
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Liver - Bile duct

0
(C57BL/6 x C3H)F1 Liver - Bile duct tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Liver - Bile duct

observed
(C57BL/6 x C3H)F1 Liver adenoma
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Liver

observed
(C57BL/6 x C3H)F1 Liver adenoma
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Liver

observed
(C57BL/6 x C3H)F1 Liver adenoma
  • chlorinated paraffins
 Liver

observed
(C57BL/6 x C3H)F1 Liver adenoma
  • 4-aminobiphenyl
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • cobalt sulfate heptahydrate
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • agar
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • cytembena
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • allyl isothiocyanate
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • acrylonitrile
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Liver

0
(C57BL/6 x C3H)F1 Liver adenoma
  • 2-amino-4-nitrophenol
 Liver

0
(C57BL/6 x C3H)F1 Liver carcinoma
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Liver

observed
(C57BL/6 x C3H)F1 Liver carcinoma
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Liver

observed
(C57BL/6 x C3H)F1 Liver lesion
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Liver

observed
(C57BL/6 x C3H)F1 Liver lesion
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Liver

observed
(C57BL/6 x C3H)F1 Liver tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Liver

observed
(C57BL/6 x C3H)F1 Liver tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Liver

observed
(C57BL/6 x C3H)F1 Liver tumor
  • chlorinated paraffins
 Liver

observed
(C57BL/6 x C3H)F1 Liver tumor
  • 4-aminobiphenyl
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • cobalt sulfate heptahydrate
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • agar
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • cytembena
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • allyl isothiocyanate
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • acrylonitrile
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Liver

0
(C57BL/6 x C3H)F1 Liver tumor
  • 2-amino-4-nitrophenol
 Liver

0
(C57BL/6 x C3H)F1 Lung tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Lung

observed
(C57BL/6 x C3H)F1 Lung tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Lung

observed
(C57BL/6 x C3H)F1 Lung tumor
  • chlorinated paraffins
 Lung

0
(C57BL/6 x C3H)F1 Lung tumor
  • 4-aminobiphenyl
 Lung

0
(C57BL/6 x C3H)F1 Lung tumor
  • cobalt sulfate heptahydrate
 Lung

0
(C57BL/6 x C3H)F1 Lung tumor
  • agar
 Lung

observed
(C57BL/6 x C3H)F1 Lung tumor
  • cytembena
 Lung

0
(C57BL/6 x C3H)F1 Lung tumor
  • allyl isothiocyanate
 Lung

0
(C57BL/6 x C3H)F1 Lung tumor
  • acrylonitrile
 Lung

observed
(C57BL/6 x C3H)F1 Lung tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Lung

0
(C57BL/6 x C3H)F1 Lung tumor
  • 2-amino-4-nitrophenol
 Lung

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Mammary gland

0 - observed
(C57BL/6 x C3H)F1 Mammary gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Mammary gland

observed
(C57BL/6 x C3H)F1 Mammary gland tumor
  • chlorinated paraffins
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • 4-aminobiphenyl
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • cobalt sulfate heptahydrate
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • agar
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • cytembena
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • allyl isothiocyanate
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • acrylonitrile
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Mammary gland

0
(C57BL/6 x C3H)F1 Mammary gland tumor
  • 2-amino-4-nitrophenol
 Mammary gland

0
(C57BL/6 x C3H)F1 Nose tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Nose

observed
(C57BL/6 x C3H)F1 Nose tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Nose

observed
(C57BL/6 x C3H)F1 Oral cavity tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Oral cavity

observed
(C57BL/6 x C3H)F1 Oral cavity tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Oral cavity

observed
(C57BL/6 x C3H)F1 Oral cavity tumor
  • chlorinated paraffins
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • 4-aminobiphenyl
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • cobalt sulfate heptahydrate
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • agar
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • cytembena
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • allyl isothiocyanate
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • acrylonitrile
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Oral cavity

0
(C57BL/6 x C3H)F1 Oral cavity tumor
  • 2-amino-4-nitrophenol
 Oral cavity

0
(C57BL/6 x C3H)F1 Ovary tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Ovary

observed
(C57BL/6 x C3H)F1 Ovary tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Ovary

observed
(C57BL/6 x C3H)F1 Pancreas tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • chlorinated paraffins
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • 4-aminobiphenyl
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • cobalt sulfate heptahydrate
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • agar
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • cytembena
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • allyl isothiocyanate
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • acrylonitrile
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Pancreas

0
(C57BL/6 x C3H)F1 Pancreas tumor
  • 2-amino-4-nitrophenol
 Pancreas

0
(C57BL/6 x C3H)F1 Peritoneal cavity tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Peritoneal cavity

observed
(C57BL/6 x C3H)F1 Peritoneal cavity tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Peritoneal cavity

observed
(C57BL/6 x C3H)F1 Pituitary gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Pituitary gland

observed
(C57BL/6 x C3H)F1 Pituitary gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Pituitary gland

observed
(C57BL/6 x C3H)F1 Preputial gland (male) tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Preputial gland (male)

observed
(C57BL/6 x C3H)F1 Preputial gland (male) tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Preputial gland (male)

observed
(C57BL/6 x C3H)F1 Prostate gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • chlorinated paraffins
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • 4-aminobiphenyl
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • cobalt sulfate heptahydrate
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • agar
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • cytembena
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • allyl isothiocyanate
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • acrylonitrile
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Prostate gland

0
(C57BL/6 x C3H)F1 Prostate gland tumor
  • 2-amino-4-nitrophenol
 Prostate gland

0
(C57BL/6 x C3H)F1 Skin tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Skin

observed
(C57BL/6 x C3H)F1 Skin tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Skin

observed
(C57BL/6 x C3H)F1 Skin tumor
  • chlorinated paraffins
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • 4-aminobiphenyl
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • cobalt sulfate heptahydrate
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • agar
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • cytembena
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • allyl isothiocyanate
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • acrylonitrile
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Skin

0
(C57BL/6 x C3H)F1 Skin tumor
  • 2-amino-4-nitrophenol
 Skin

0
(C57BL/6 x C3H)F1 Spleen tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Spleen

0 - observed
(C57BL/6 x C3H)F1 Spleen tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Spleen

observed
(C57BL/6 x C3H)F1 Stomach tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Stomach

observed
(C57BL/6 x C3H)F1 Stomach tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Stomach

observed
(C57BL/6 x C3H)F1 Subcutis tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Subcutis

0 - observed
(C57BL/6 x C3H)F1 Subcutis tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Subcutis

observed
(C57BL/6 x C3H)F1 Testis tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Testis

observed
(C57BL/6 x C3H)F1 Testis tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Testis

observed
(C57BL/6 x C3H)F1 Thymus tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Thymus

observed
(C57BL/6 x C3H)F1 Thymus tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Thymus

observed
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Thyroid gland

observed
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Thyroid gland

observed
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • chlorinated paraffins
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • 4-aminobiphenyl
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • cobalt sulfate heptahydrate
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • agar
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • cytembena
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • allyl isothiocyanate
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • acrylonitrile
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Thyroid gland

0
(C57BL/6 x C3H)F1 Thyroid gland tumor
  • 2-amino-4-nitrophenol
 Thyroid gland

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • chlorinated paraffins
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • 4-aminobiphenyl
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • cobalt sulfate heptahydrate
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • agar
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • cytembena
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • allyl isothiocyanate
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • acrylonitrile
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Tunica vaginalis tumor
  • 2-amino-4-nitrophenol
 Tunica vaginalis

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Urinary bladder

observed
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Urinary bladder

observed
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • chlorinated paraffins
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • 4-aminobiphenyl
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • cobalt sulfate heptahydrate
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • agar
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • cytembena
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • allyl isothiocyanate
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • acrylonitrile
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urinary bladder tumor
  • 2-amino-4-nitrophenol
 Urinary bladder

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • chlorinated paraffins
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • 4-aminobiphenyl
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • cobalt sulfate heptahydrate
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • agar
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • cytembena
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • allyl isothiocyanate
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • acrylonitrile
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Urogenital tract

0
(C57BL/6 x C3H)F1 Urogenital tract tumor
  • 2-amino-4-nitrophenol
 Urogenital tract

0
(C57BL/6 x C3H)F1 Uterus tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 Uterus

observed
(C57BL/6 x C3H)F1 Uterus tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 Uterus

observed
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • single carcinogen from 185 carcinogen National Toxicology Program pool
 (Unspecified organ)

0 - observed
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • single carcinogen from 536 carcinogen pool that includes the 185 National Toxicology Program carcinogens
 (Unspecified organ)

0 - observed
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • chlorinated paraffins
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • 4-aminobiphenyl
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • cobalt sulfate heptahydrate
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • agar
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • cytembena
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • allyl isothiocyanate
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • acrylonitrile
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • 2-amino-4-nitrophenol
 (Unspecified organ)

0