Reference SummaryHanahan D, Nature 1985 May 9-15;315(6015):115-22

Title

 Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.

Authors

 Hanahan D

Journal

 Nature

Volume

 315

Issue

 6015

Year

 1985

Pages

 115-22

Abstract

 Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.

Links

 J:50695 – MGI References
2986015 – National Library of Medicine/PubMed

Strain Notes

Strain Note
B6;D2-Tg(RIP1-Tag)2Dh Expression of the "RIP1-Tag" transgene was reported to not be detected in the intestines, kidneys, liver, lungs, muscle, skin, spleen, stomach, testis, and thymus of these mice.
The "RIP1-Tag2" transgene was reported to be expressed in the pancreas of these mice.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
B6;D2-Tg(RIP1-Tag)2Dh Pancreas - Islet of Langerhans - Beta cell hyperplasia Pancreas - Islet of Langerhans - Beta cell

very high
B6;D2-Tg(RIR-Tag)#Dh Pancreas - Islet of Langerhans - Beta cell hyperplasia Pancreas - Islet of Langerhans - Beta cell

observed
B6;D2-Tg(RIP1-Tag)2Dh Pancreas - Islet of Langerhans - Beta cell tumor
  • high sugar
 Pancreas - Islet of Langerhans - Beta cell

very high
B6;D2-Tg(RIR-Tag)#Dh Pancreas - Islet of Langerhans - Beta cell tumor Pancreas - Islet of Langerhans - Beta cell

observed