Reference SummaryToth B, Carcinogenesis 1980 Jul;1(7):589-93

Title

 Tumorigenic action of N-n-butyl-N-formylhydrazine in mice.

Authors

 Toth B; Nagel D; Patil K

Journal

 Carcinogenesis

Volume

 1

Issue

 7

Year

 1980

Pages

 589-93

Abstract

 Continuous administration of 0.04% N-n-butyl-N-formylhydrazine (BFH) in drinking water to 6-week-old randomly bred Swiss mice for life produced tumors of the lungs, preputial and clitoral glands. The tumor incidences in these three tissues of the treated animals were 87, 66, and 10%, whereas in the untreated controls they were 25, 0, and 0%, respectively. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs, squamous cell papillomas and carcinomas, angio-, fibro-, and myxo- sarcomas of preputial glands and squamous cell papillomas and carcinomas of clitoral glands. N-n-Butyl-N-formylhydrazine is a structural homologue of the carcinogenic N-methyl-N-formylhydrazine and N-ethyl-N-formylhydrazine. These studies are integral parts of structure activity relationship inquiries.

Links

 J:67441 – MGI References
11219834 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
Swiss Adrenal gland - Cortex adenoma Adrenal gland - Cortex

1
Swiss Clitoral gland squamous cell carcinoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Clitoral gland

8
Swiss Clitoral gland squamous cell papilloma
  • N-n-butyl-N-formylhydrazine (BFH)
 Clitoral gland

2
Swiss Clitoral gland tumor
  • N-n-butyl-N-formylhydrazine (BFH)
 Clitoral gland

10
Swiss Clitoral gland tumor Clitoral gland

0
Swiss Connective tissue - Fibroblast adenocarcinoma Salivary gland - Submandibular

1
Swiss Connective tissue - Fibroblast fibroma Mammary gland

1
Swiss Connective tissue - Fibroblast fibrosarcoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

10
Swiss Connective tissue - Fibroblast fibrosarcoma Subcutis

1 - 2
Swiss Esophagus papilloma
  • N-n-butyl-N-formylhydrazine (BFH)
 Esophagus

2
Swiss Forestomach carcinoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Forestomach

2
Swiss Forestomach papilloma
  • N-n-butyl-N-formylhydrazine (BFH)
 Forestomach

2
Swiss Forestomach papilloma Forestomach

4
Swiss Gallbladder adenoma Gallbladder

1
Swiss Intestine - Large Intestine - Colon adenoma - polypoid Intestine - Large Intestine - Colon

1
Swiss Kidney adenocarcinoma Kidney

1
Swiss Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1
Swiss Leukocyte lymphoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Leukocyte

6 - 14
Swiss Leukocyte lymphoma Leukocyte

8 - 18
Swiss Liver hepatoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Liver

2
Swiss Liver hepatoma Liver

1
Swiss Lung adenocarcinoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Lung

40 - 68
Swiss Lung adenoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Lung

84 - 90
Swiss Lung tumor
  • N-n-butyl-N-formylhydrazine (BFH)
 Lung

84 - 90
Swiss Lung tumor Lung

25 - 26
Swiss Mammary gland adenocarcinoma Mammary gland

2
Swiss Mesodermal cell/mesoblast myxosarcoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

2
Swiss Mesodermal cell/mesoblast myxosarcoma Uterus

1
Swiss Mesodermal cell/mesoblast sarcoma Retroperitoneum

1
Swiss Ovary - Granulosa cell tumor - granulosa cell Ovary - Granulosa cell

1
Swiss Pancreas - Islet of Langerhans adenoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Pancreas - Islet of Langerhans

2
Swiss Preputial gland (male) adenocarcinoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

2
Swiss Preputial gland (male) carcinoma - undifferentiated
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

2
Swiss Preputial gland (male) squamous cell carcinoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

40
Swiss Preputial gland (male) squamous cell papilloma
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

4
Swiss Preputial gland (male) tumor
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

66
Swiss Preputial gland (male) tumor Preputial gland (male)

0
Swiss Salivary gland - Submandibular adenocarcinoma Salivary gland - Submandibular

1
Swiss Skin carcinoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Skin

2
Swiss Skin gland - Sebaceous gland adenoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Skin gland - Sebaceous gland

2
Swiss Skin keratoacanthoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Skin

2
Swiss (Unspecified organ) angioma
  • N-n-butyl-N-formylhydrazine (BFH)
 Spleen

2 - 8
Swiss (Unspecified organ) angioma
  • N-n-butyl-N-formylhydrazine (BFH)
 Ovary

8
Swiss (Unspecified organ) angioma
  • N-n-butyl-N-formylhydrazine (BFH)
 Uterus

8
Swiss (Unspecified organ) angioma
  • N-n-butyl-N-formylhydrazine (BFH)
 Clitoral gland

8
Swiss (Unspecified organ) angioma
  • N-n-butyl-N-formylhydrazine (BFH)
 Liver

4
Swiss (Unspecified organ) angioma Liver

6 - 8
Swiss (Unspecified organ) angioma Uterus

6
Swiss (Unspecified organ) angioma Ovary

6
Swiss (Unspecified organ) angiosarcoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Preputial gland (male)

6
Swiss (Unspecified organ) angiosarcoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Liver

8
Swiss (Unspecified organ) angiosarcoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Spleen

8
Swiss (Unspecified organ) angiosarcoma
  • N-n-butyl-N-formylhydrazine (BFH)
 Ovary

8
Swiss (Unspecified organ) angiosarcoma Liver

4
Swiss (Unspecified organ) angiosarcoma Uterus

4