Reference SummaryMoser AR, Cancer Res 2001 Apr 15;61(8):3480-5

Title

 Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.

Authors

 Moser AR; Hegge LF; Cardiff RD

Journal

 Cancer Res

Volume

 61

Issue

 8

Year

 2001

Pages

 3480-5

Abstract

 Treatment of female C57BL/6J (B6) mice carrying the mutant Min allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approximately 90% of mice developing an average of three mammary tumors within 65 days. As a first step in the identification of loci modifying susceptibility to ENU-induced mammary tumors and hyperplasias, we have tested ENU-treated Apc(Min)/+ (Min/+) mice on several hybrid backgrounds for susceptibility to mammary and intestinal tumors. C57BR/cdJxB6 (BRB6) Min/+ mice were more sensitive to development of mammary squamous cell carcinomas than B6 Min/+ mice. In contrast, Min/+ hybrids between B6 and FVB/NTac (FVB), 129X1/SvJ (129X1), and 129S6/SvEvTac (129S6) were all significantly more resistant to mammary carcinoma development. However, mice from these three crosses developed more focal mammary hyperplasias than did the B6 or BRB6 Min/+ mice. Susceptibility to intestinal tumors was independent of mammary tumor susceptibility in most hybrids. These results indicate that genetic background can affect independently the phenotypes conferred by the Min allele of APC:

Links

 J:68915 – MGI References
11309311 – National Library of Medicine/PubMed

Strain Notes

Strain Note
129S6B6F1-ApcMin/+ C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with 129S6/SvEvTac females from Taconic.
(129S6/SvEvTac x C57BL/6J)F1 C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with 129S6/SvEvTac females from Taconic. Wild type littermate controls.
129X1B6F1-ApcMin/+ C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with 129X1/SvJ females from The Jackson Laboratory.
(129X1/SvJ x C57BL/6J)F1 C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with 129X1/SvJ females from The Jackson Laboratory. Wild type littermate controls.
BRB6F1-ApcMin/+ C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with C57BR/cdJ females from The Jackson Laboratory.
(C57BR/cdJ x C57BL/6J)F1 C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with C57BR/cdJ females from The Jackson Laboratory. Wild type littermate controls.
FVBB6F1-ApcMin/+ C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with FVB/NTac females from Taconic.
(FVB/NTac x C57BL/6J)F1 C57BL/6J-ApcMin/+ males bred at the University of Wisconsin were mated with FVB/NTac females from Taconic. Wild type littermate controls.
Visual Summary Grid

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine tumor Intestine

100
C57BL/6J-ApcMin/+ Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

100
C57BL/6J Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

0
BRB6F1-ApcMin/+ Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

100
BRB6F1-ApcMin/+ Intestine tumor Intestine

100
(C57BR/cdJ x C57BL/6J)F1 Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

0
129S6B6F1-ApcMin/+ Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

100
129S6B6F1-ApcMin/+ Intestine tumor Intestine

100
(129S6/SvEvTac x C57BL/6J)F1 Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

0
129X1B6F1-ApcMin/+ Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

100
129X1B6F1-ApcMin/+ Intestine tumor Intestine

100
(129X1/SvJ x C57BL/6J)F1 Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

0
FVBB6F1-ApcMin/+ Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

100
FVBB6F1-ApcMin/+ Intestine tumor Intestine

100
(FVB/NTac x C57BL/6J)F1 Intestine tumor
  • ethylnitrosourea (ENU)
 Intestine

0
C57BL/6J-ApcMin/+ Mammary gland lesion
  • ethylnitrosourea (ENU)
 Mammary gland

38
BRB6F1-ApcMin/+ Mammary gland lesion
  • ethylnitrosourea (ENU)
 Mammary gland

39
129S6B6F1-ApcMin/+ Mammary gland lesion
  • ethylnitrosourea (ENU)
 Mammary gland

65
129X1B6F1-ApcMin/+ Mammary gland lesion
  • ethylnitrosourea (ENU)
 Mammary gland

73
(129X1/SvJ x C57BL/6J)F1 Mammary gland lesion
  • ethylnitrosourea (ENU)
 Mammary gland

observed
FVBB6F1-ApcMin/+ Mammary gland lesion
  • ethylnitrosourea (ENU)
 Mammary gland

100
C57BL/6J-ApcMin/+ Mammary gland tumor Mammary gland

0 - 5
C57BL/6J-ApcMin/+ Mammary gland tumor
  • ethylnitrosourea (ENU)
 Mammary gland

93
C57BL/6J Mammary gland tumor Mammary gland

0
BRB6F1-ApcMin/+ Mammary gland tumor
  • ethylnitrosourea (ENU)
 Mammary gland

94
BRB6F1-ApcMin/+ Mammary gland tumor Mammary gland

0
(C57BR/cdJ x C57BL/6J)F1 Mammary gland tumor Mammary gland

0
129S6B6F1-ApcMin/+ Mammary gland tumor
  • ethylnitrosourea (ENU)
 Mammary gland

41
129S6B6F1-ApcMin/+ Mammary gland tumor Mammary gland

0
(129S6/SvEvTac x C57BL/6J)F1 Mammary gland tumor Mammary gland

0
129X1B6F1-ApcMin/+ Mammary gland tumor
  • ethylnitrosourea (ENU)
 Mammary gland

9.1
129X1B6F1-ApcMin/+ Mammary gland tumor Mammary gland

0
(129X1/SvJ x C57BL/6J)F1 Mammary gland tumor Mammary gland

0
FVBB6F1-ApcMin/+ Mammary gland tumor
  • ethylnitrosourea (ENU)
 Mammary gland

17
FVBB6F1-ApcMin/+ Mammary gland tumor Mammary gland

0
(FVB/NTac x C57BL/6J)F1 Mammary gland tumor Mammary gland

0