Reference SummaryYu W, Toxicol Appl Pharmacol 1999 Jul 15;158(2):161-76
Title |
Preconception urethane or chromium(III) treatment of male mice: multiple neoplastic and non-neoplastic changes in offspring. |
Authors |
Yu W; Sipowicz MA; Haines DC; Birely L; Diwan BA; Riggs CW; Kasprzak KS; Anderson LM |
Journal |
Toxicol Appl Pharmacol |
Volume |
158 |
Issue |
2 |
Year |
1999 |
Pages |
161-76 |
Abstract |
Increase in neoplasia in offspring after preconception exposure of parents presents puzzling features such as high frequency of effects and lack of Mendelian inheritance. The present study examined the hypothesis that preconception carcinogenesis involves an increase in the rate of occurrence of neoplasms with a spontaneous incidence. Male NIH Swiss mice (12 per group) were exposed 2 weeks before mating (once, ip) to urethane (1.5 g/kg) or chromium(III) chloride (1 mmol/kg). Offspring (48-78/sex/group) were examined for all grossly apparent changes when moribund or at natural death, followed by histopathological diagnosis and statistical analysis. Significant exposure-related changes occurred in multiple organs. Ten to 20 percent of offspring showed changes related to paternal exposure, including at least one sired by most treated males. Pheochromocytomas occurred in both male and female offspring after both treatments, with none in controls. These neoplasms are rare in mice and suggest endocrine dysfunction as a component of preconception carcinogenesis. This was supported by increases in thyroid follicular cell and Harderian gland tumors, ovarian cysts, and uterine abnormalities. Lung tumors were increased in female offspring only. Effects seen in offspring only after paternal urethane exposure were an increase in preneoplasia/neoplasia in the glandular stomach (males) and in females, increased lymphoma but decreased incidence of histiocytic sarcoma. Increases in incidence of male reproductive gland tumors and of renal non-neoplastic lesions occurred only after chromium exposure. Thus, preconception exposure of fathers to toxicants had a significant impact on both neoplastic and non-neoplastic changes in almost all tissues in which these lesions often occur naturally during the aging process. |
Links |
J:70184 – MGI References 10406931 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| Swiss/N | Adrenal gland - Cortex adenoma |
|
Adrenal gland - Cortex |
1.9 |
|
| Swiss/N | Adrenal gland - Medulla pheochromocytoma |
|
Adrenal gland - Medulla |
3.7 - 3.8 |
|
| Swiss/N | Adrenal gland - Medulla pheochromocytoma |
|
Adrenal gland - Medulla |
2.8 - 7.0 |
|
| Swiss/N | Adrenal gland lesion |
|
Adrenal gland |
7.4 - 15 |
|
| Swiss/N | Adrenal gland lesion |
|
Adrenal gland |
5.6 - 18 |
|
| Swiss/N | Adrenal gland lesion | Adrenal gland |
7.0 - 8.3 |
||
| Swiss/N | Adrenal gland tumor |
|
Adrenal gland |
3.8 - 5.6 |
|
| Swiss/N | Adrenal gland tumor |
|
Adrenal gland |
2.8 - 7.0 |
|
| Swiss/N | Adrenal gland tumor | Adrenal gland |
0 |
||
| Swiss/N | Blood vessel hemangioma |
|
Blood vessel |
1.3 - 1.9 |
|
| Swiss/N | Blood vessel hemangioma |
|
Blood vessel |
0 - 1.4 |
|
| Swiss/N | Blood vessel hemangioma | Blood vessel |
0 |
||
| Swiss/N | Blood vessel hemangiosarcoma |
|
Blood vessel |
1.9 - 7.7 |
|
| Swiss/N | Blood vessel hemangiosarcoma |
|
Ovary |
1.3 |
|
| Swiss/N | Blood vessel hemangiosarcoma |
|
Uterus |
1.3 |
|
| Swiss/N | Blood vessel hemangiosarcoma |
|
Uterus - Cervix |
1.3 |
|
| Swiss/N | Blood vessel hemangiosarcoma |
|
Blood vessel |
4.2 - 5.6 |
|
| Swiss/N | Blood vessel hemangiosarcoma |
|
Uterus |
2.8 |
|
| Swiss/N | Blood vessel hemangiosarcoma | Blood vessel |
4.2 - 13 |
||
| Swiss/N | Blood vessel hemangiosarcoma | Ovary |
5.6 |
||
| Swiss/N | Blood vessel hemangiosarcoma | Uterus |
4.2 |
||
| Swiss/N | Blood vessel hemangiosarcoma |
|
Seminal vesicle |
1.3 |
|
| Swiss/N | Blood vessel hemangiosarcoma | Seminal vesicle |
1.2 |
||
| Swiss/N | Bone osteosarcoma |
|
Bone |
0 |
|
| Swiss/N | Bone osteosarcoma |
|
Bone |
0 |
|
| Swiss/N | Bone osteosarcoma | Bone |
0 - 1.4 |
||
| Swiss/N | Bulbourethral gland cystadenoma |
|
Bulbourethral gland |
2.2 |
|
| Swiss/N | Bulbourethral gland lesion |
|
Bulbourethral gland |
16 |
|
| Swiss/N | Bulbourethral gland lesion |
|
Bulbourethral gland |
17 |
|
| Swiss/N | Bulbourethral gland lesion | Bulbourethral gland |
8.1 |
||
| Swiss/N | Bulbourethral gland neoplasm |
|
Bulbourethral gland |
1.3 |
|
| Swiss/N | Bulbourethral gland neoplasm |
|
Bulbourethral gland |
3.3 |
|
| Swiss/N | Bulbourethral gland neoplasm | Bulbourethral gland |
0 |
||
| Swiss/N | Bulbourethral gland polyp |
|
Bulbourethral gland |
1.3 |
|
| Swiss/N | Bulbourethral gland polyp |
|
Bulbourethral gland |
1.1 |
|
| Swiss/N | CNS - Brain - Choroid plexus tumor |
|
CNS - Brain - Choroid plexus |
1.4 |
|
| Swiss/N | CNS - Brain - Oligodendroglial cell oligodendroglioma |
|
CNS - Brain - Oligodendroglial cell |
1.4 |
|
| Swiss/N | Connective tissue - Fibroblast fibrosarcoma |
|
Connective tissue - Fibroblast |
0 - 1.3 |
|
| Swiss/N | Connective tissue - Fibroblast fibrosarcoma |
|
Connective tissue - Fibroblast |
1.4 |
|
| Swiss/N | Connective tissue - Fibroblast fibrosarcoma |
|
Uterus |
1.4 |
|
| Swiss/N | Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
0 |
||
| Swiss/N | Eye - Harderian gland adenoma |
|
Eye - Harderian gland |
6.4 - 11 |
|
| Swiss/N | Eye - Harderian gland adenoma |
|
Eye - Harderian gland |
5.6 - 15 |
|
| Swiss/N | Eye - Harderian gland adenoma | Eye - Harderian gland |
1.4 - 4.7 |
||
| Swiss/N | Eye - Harderian gland carcinoma |
|
Eye - Harderian gland |
2.6 |
|
| Swiss/N | Eye - Harderian gland carcinoma | Eye - Harderian gland |
2.8 |
||
| Swiss/N | Eye - Harderian gland carcinosarcoma | Eye - Harderian gland |
1.2 |
||
| Swiss/N | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
9.0 - 11 |
|
| Swiss/N | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
5.6 - 15 |
|
| Swiss/N | Eye - Harderian gland tumor | Eye - Harderian gland |
4.2 - 5.8 |
||
| Swiss/N | Forestomach squamous cell papilloma |
|
Forestomach |
1.4 |
|
| Swiss/N | Head squamous cell carcinoma | Head |
1.4 |
||
| Swiss/N | Kidney adenoma |
|
Kidney |
1.4 |
|
| Swiss/N | Kidney adenoma |
|
Kidney |
1.1 |
|
| Swiss/N | Kidney carcinoma |
|
Kidney |
1.4 |
|
| Swiss/N | Kidney cyst |
|
Kidney |
9.5 |
|
| Swiss/N | Kidney cyst |
|
Kidney |
17 |
|
| Swiss/N | Kidney cyst | Kidney |
7.0 |
||
| Swiss/N | Kidney lesion |
|
Kidney |
12 |
|
| Swiss/N | Kidney lesion |
|
Kidney |
24 |
|
| Swiss/N | Kidney lesion | Kidney |
12 |
||
| Swiss/N | Kidney neoplasm |
|
Kidney |
0 - 2.7 |
|
| Swiss/N | Kidney neoplasm |
|
Kidney |
0 - 2.2 |
|
| Swiss/N | Kidney neoplasm | Kidney |
0 |
||
| Swiss/N | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma - follicular |
|
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell |
9.3 - 14 |
|
| Swiss/N | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma - follicular |
|
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell |
4.2 - 7.0 |
|
| Swiss/N | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma - follicular | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell |
4.2 - 8.5 |
||
| Swiss/N | Leukocyte - Lymphocyte lymphoma - lymphoblastic |
|
Leukocyte - Lymphocyte |
0 - 12 |
|
| Swiss/N | Leukocyte - Lymphocyte lymphoma - lymphoblastic |
|
Leukocyte - Lymphocyte |
0 - 4.2 |
|
| Swiss/N | Leukocyte - Lymphocyte lymphoma - lymphoblastic | Leukocyte - Lymphocyte |
0 - 9.9 |
||
| Swiss/N | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 3.7 |
|
| Swiss/N | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
2.8 - 8.5 |
|
| Swiss/N | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
2.1 - 8.5 |
||
| Swiss/N | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Seminal vesicle |
1.1 |
|
| Swiss/N | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Liver |
1.1 |
|
| Swiss/N | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor |
|
Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
1.9 - 2.6 |
|
| Swiss/N | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor |
|
Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
1.4 |
|
| Swiss/N | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
0 - 1.4 |
||
| Swiss/N | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
0 - 1.3 |
|
| Swiss/N | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
1.4 |
|
| Swiss/N | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 - 2.1 |
||
| Swiss/N | Leukocyte lymphoma |
|
Leukocyte |
9.3 - 27 |
|
| Swiss/N | Leukocyte lymphoma |
|
Leukocyte |
6.9 - 11 |
|
| Swiss/N | Leukocyte lymphoma | Leukocyte |
4.2 - 21 |
||
| Swiss/N | Leukocyte lymphoma - immunoblastic |
|
Leukocyte |
0 |
|
| Swiss/N | Leukocyte lymphoma - immunoblastic |
|
Leukocyte |
0 - 1.4 |
|
| Swiss/N | Leukocyte lymphoma - immunoblastic | Leukocyte |
0 - 1.4 |
||
| Swiss/N | Leukocyte lymphoma - unclassified |
|
Leukocyte |
0 - 1.3 |
|
| Swiss/N | Leukocyte lymphoma - unclassified |
|
Leukocyte |
0 - 1.4 |
|
| Swiss/N | Leukocyte lymphoma - unclassified | Leukocyte |
0 - 1.4 |
||
| Swiss/N | Liver hepatocellular adenoma | Liver |
1.2 |
||
| Swiss/N | Liver lesion |
|
Liver |
24 |
|
| Swiss/N | Liver lesion |
|
Liver |
20 |
|
| Swiss/N | Liver lesion | Liver |
10 |
||
| Swiss/N | Liver neoplasm |
|
Liver |
0 |
|
| Swiss/N | Liver neoplasm |
|
Liver |
1.1 |
|
| Swiss/N | Liver neoplasm | Liver |
1.2 |
||
| Swiss/N | Liver preneoplastic lesion |
|
Liver |
0 |
|
| Swiss/N | Liver preneoplastic lesion |
|
Liver |
3.3 |
|
| Swiss/N | Liver preneoplastic lesion | Liver |
0 |
||
| Swiss/N | Lung - Alveolus tumor |
|
Lung - Alveolus |
54 - 61 |
|
| Swiss/N | Lung - Alveolus tumor |
|
Lung - Alveolus |
60 - 70 |
|
| Swiss/N | Lung - Alveolus tumor | Lung - Alveolus |
54 - 55 |
||
| Swiss/N | Mammary gland adenocarcinoma |
|
Mammary gland |
6.4 |
|
| Swiss/N | Mammary gland adenocarcinoma |
|
Mammary gland |
7.0 |
|
| Swiss/N | Mammary gland adenocarcinoma | Mammary gland |
5.6 |
||
| Swiss/N | Mammary gland carcinosarcoma |
|
Mammary gland |
1.3 |
|
| Swiss/N | Mammary gland carcinosarcoma | Mammary gland |
1.4 |
||
| Swiss/N | Mammary gland hyperplasia |
|
Mammary gland |
5.1 |
|
| Swiss/N | Mammary gland hyperplasia |
|
Mammary gland |
2.8 |
|
| Swiss/N | Mammary gland hyperplasia | Mammary gland |
4.2 |
||
| Swiss/N | Mammary gland lesion |
|
Mammary gland |
13 |
|
| Swiss/N | Mammary gland lesion |
|
Mammary gland |
8.5 |
|
| Swiss/N | Mammary gland lesion | Mammary gland |
13 |
||
| Swiss/N | Mammary gland metaplasia |
|
Mammary gland |
1.3 |
|
| Swiss/N | Mammary gland metaplasia |
|
Mammary gland |
0 |
|
| Swiss/N | Mammary gland metaplasia | Mammary gland |
0 |
||
| Swiss/N | Mammary gland neoplasm |
|
Mammary gland |
7.7 |
|
| Swiss/N | Mammary gland neoplasm |
|
Mammary gland |
7.0 |
|
| Swiss/N | Mammary gland neoplasm | Mammary gland |
7.0 |
||
| Swiss/N | Mesodermal cell/mesoblast myxosarcoma |
|
Mesodermal cell/mesoblast |
0 |
|
| Swiss/N | Mesodermal cell/mesoblast myxosarcoma |
|
Mesodermal cell/mesoblast |
0 |
|
| Swiss/N | Mesodermal cell/mesoblast myxosarcoma | Mesodermal cell/mesoblast |
0 - 1.4 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma |
|
Uterus - Endometrium - Stroma |
0 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma |
|
Uterus - Endometrium - Stroma |
1.4 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma | Uterus - Endometrium - Stroma |
0 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma |
|
Seminal vesicle |
6.7 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma |
|
Seminal vesicle |
11 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma |
|
Kidney |
1.1 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma | Seminal vesicle |
4.7 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma - stromal |
|
Uterus - Endometrium - Stroma |
1.4 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Mesodermal cell/mesoblast |
2.6 - 13 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Intestine - Large Intestine - Cecum |
1.3 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Subcutis |
1.3 - 1.9 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Mesodermal cell/mesoblast |
2.8 - 15 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Intestine - Large Intestine - Cecum |
1.4 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Subcutis |
1.4 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated | Mesodermal cell/mesoblast |
7.0 - 8.3 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated | Subcutis |
2.8 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated | Head |
1.4 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated | Muscle |
1.4 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated | Mediastinum |
1.4 |
||
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Pancreas |
1.9 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Seminal vesicle |
9.3 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated |
|
Seminal vesicle |
14 |
|
| Swiss/N | Mesodermal cell/mesoblast sarcoma - undifferentiated | Seminal vesicle |
8.3 |
||
| Swiss/N | Muscle - Smooth leiomyoma |
|
Muscle - Smooth |
0 |
|
| Swiss/N | Muscle - Smooth leiomyoma |
|
Muscle - Smooth |
1.4 |
|
| Swiss/N | Muscle - Smooth leiomyoma |
|
Uterus |
1.4 |
|
| Swiss/N | Muscle - Smooth leiomyoma | Muscle - Smooth |
4.2 |
||
| Swiss/N | Muscle - Smooth leiomyoma | Uterus |
4.2 |
||
| Swiss/N | Muscle - Smooth leiomyosarcoma |
|
Muscle - Smooth |
2.6 |
|
| Swiss/N | Muscle - Smooth leiomyosarcoma |
|
Uterus |
2.6 |
|
| Swiss/N | Muscle - Smooth leiomyosarcoma |
|
Muscle - Smooth |
5.6 |
|
| Swiss/N | Muscle - Smooth leiomyosarcoma |
|
Uterus |
4.2 |
|
| Swiss/N | Muscle - Smooth leiomyosarcoma |
|
Uterus - Cervix |
1.4 |
|
| Swiss/N | Muscle - Smooth leiomyosarcoma | Muscle - Smooth |
0 |
||
| Swiss/N | Oral cavity squamous cell carcinoma |
|
Oral cavity |
2.6 |
|
| Swiss/N | Oral cavity squamous cell carcinoma | Oral cavity |
2.1 - 2.8 |
||
| Swiss/N | Ovary - Granulosa cell tumor |
|
Ovary - Granulosa cell |
1.3 |
|
| Swiss/N | Ovary - Granulosa cell tumor |
|
Ovary - Granulosa cell |
1.4 |
|
| Swiss/N | Ovary cyst |
|
Ovary |
15 |
|
| Swiss/N | Ovary cyst |
|
Ovary |
18 |
|
| Swiss/N | Ovary cyst | Ovary |
7.0 |
||
| Swiss/N | Ovary lesion |
|
Ovary |
23 |
|
| Swiss/N | Ovary lesion |
|
Ovary |
27 |
|
| Swiss/N | Ovary lesion | Ovary |
20 |
||
| Swiss/N | Ovary luteoma |
|
Ovary |
1.3 |
|
| Swiss/N | Ovary luteoma | Ovary |
1.4 |
||
| Swiss/N | Ovary neoplasm |
|
Ovary |
3.8 |
|
| Swiss/N | Ovary neoplasm |
|
Ovary |
1.4 |
|
| Swiss/N | Ovary neoplasm | Ovary |
7.0 |
||
| Swiss/N | Pancreas - Islet of Langerhans adenoma |
|
Pancreas - Islet of Langerhans |
1.4 |
|
| Swiss/N | Pituitary gland - Pars distalis adenoma |
|
Pituitary gland - Pars distalis |
3.8 |
|
| Swiss/N | Pituitary gland - Pars distalis adenoma |
|
Pituitary gland - Pars distalis |
2.8 |
|
| Swiss/N | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
4.2 |
||
| Swiss/N | Pituitary gland - Pars distalis carcinoma |
|
Pituitary gland - Pars distalis |
1.3 |
|
| Swiss/N | Pituitary gland - Pars distalis carcinoma | Pituitary gland - Pars distalis |
1.4 |
||
| Swiss/N | Pituitary gland - Pars distalis tumor |
|
Pituitary gland - Pars distalis |
0 - 5.1 |
|
| Swiss/N | Pituitary gland - Pars distalis tumor |
|
Pituitary gland - Pars distalis |
0 - 2.8 |
|
| Swiss/N | Pituitary gland - Pars distalis tumor | Pituitary gland - Pars distalis |
0 - 5.6 |
||
| Swiss/N | Prostate gland adenoma | Prostate gland |
1.2 |
||
| Swiss/N | Prostate gland lesion |
|
Prostate gland |
0 |
|
| Swiss/N | Prostate gland lesion |
|
Prostate gland |
0 |
|
| Swiss/N | Prostate gland lesion | Prostate gland |
1.2 |
||
| Swiss/N | Seminal vesicle lesion |
|
Seminal vesicle |
49 |
|
| Swiss/N | Seminal vesicle lesion |
|
Seminal vesicle |
55 |
|
| Swiss/N | Seminal vesicle lesion | Seminal vesicle |
48 |
||
| Swiss/N | Seminal vesicle neoplasm |
|
Seminal vesicle |
8.0 |
|
| Swiss/N | Seminal vesicle neoplasm |
|
Seminal vesicle |
13 |
|
| Swiss/N | Seminal vesicle neoplasm | Seminal vesicle |
5.8 |
||
| Swiss/N | Seminal vesicle tumor - granular cell |
|
Seminal vesicle |
1.1 |
|
| Swiss/N | Skin - Hair follicle - Basal cell trichoepithelioma |
|
Skin - Hair follicle - Basal cell |
4.2 |
|
| Swiss/N | Skin squamous cell papilloma | Skin |
1.4 |
||
| Swiss/N | Stomach - Glandular adenoma |
|
Stomach - Glandular |
5.6 |
|
| Swiss/N | Stomach - Glandular adenoma |
|
Stomach - Glandular |
1.4 |
|
| Swiss/N | Stomach - Glandular adenoma | Stomach - Glandular |
4.2 |
||
| Swiss/N | Stomach - Glandular carcinoma | Stomach - Glandular |
1.4 |
||
| Swiss/N | Stomach - Glandular carcinoma |
|
Stomach - Glandular |
5.6 |
|
| Swiss/N | Stomach - Glandular hyperplasia - atypical |
|
Stomach - Glandular |
7.4 |
|
| Swiss/N | Stomach - Glandular tumor |
|
Stomach - Glandular |
0 - 19 |
|
| Swiss/N | Stomach - Glandular tumor |
|
Stomach - Glandular |
0 - 1.4 |
|
| Swiss/N | Stomach - Glandular tumor | Stomach - Glandular |
1.4 - 4.2 |
||
| Swiss/N | Testis lesion |
|
Testis |
41 |
|
| Swiss/N | Testis lesion |
|
Testis |
35 |
|
| Swiss/N | Testis lesion | Testis |
30 |
||
| Swiss/N | Thymus thymoma |
|
Thymus |
0 |
|
| Swiss/N | Thymus thymoma |
|
Thymus |
0 |
|
| Swiss/N | Thymus thymoma | Thymus |
0 - 1.4 |
||
| Swiss/N | Thyroid gland - Follicular cell adenoma |
|
Thyroid gland - Follicular cell |
1.9 - 6.4 |
|
| Swiss/N | Thyroid gland - Follicular cell adenoma |
|
Thyroid gland - Follicular cell |
4.2 - 7.0 |
|
| Swiss/N | Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
2.8 |
||
| Swiss/N | Thyroid gland - Follicular cell carcinoma |
|
Thyroid gland - Follicular cell |
2.8 |
|
| Swiss/N | Thyroid gland - Follicular cell tumor |
|
Thyroid gland - Follicular cell |
1.9 - 6.4 |
|
| Swiss/N | Thyroid gland - Follicular cell tumor |
|
Thyroid gland - Follicular cell |
6.9 - 7.0 |
|
| Swiss/N | Thyroid gland - Follicular cell tumor | Thyroid gland - Follicular cell |
0 - 2.8 |
||
| Swiss/N | Thyroid gland lesion |
|
Thyroid gland |
1.9 - 10 |
|
| Swiss/N | Thyroid gland lesion |
|
Thyroid gland |
9.9 - 11 |
|
| Swiss/N | Thyroid gland lesion | Thyroid gland |
4.2 |
||
| Swiss/N | Ureter transitional cell carcinoma | Ureter |
2.1 |
||
| Swiss/N | Uterus - Cervix neoplasm |
|
Uterus - Cervix |
1.3 |
|
| Swiss/N | Uterus - Cervix neoplasm |
|
Uterus - Cervix |
1.4 |
|
| Swiss/N | Uterus - Cervix neoplasm | Uterus - Cervix |
0 |
||
| Swiss/N | Uterus - Endometrium - Stroma polyp |
|
Uterus - Endometrium - Stroma |
1.4 |
|
| Swiss/N | Uterus - Endometrium - Stroma polyp | Uterus - Endometrium - Stroma |
1.4 |
||
| Swiss/N | Uterus - Endometrium adenocarcinoma | Uterus - Endometrium |
1.4 |
||
| Swiss/N | Uterus - Endometrium adenoma |
|
Uterus - Endometrium |
1.3 |
|
| Swiss/N | Uterus - Endometrium carcinoma |
|
Uterus - Endometrium |
1.3 |
|
| Swiss/N | Uterus - Endometrium hyperplasia - cystic |
|
Uterus - Endometrium |
31 |
|
| Swiss/N | Uterus - Endometrium hyperplasia - cystic |
|
Uterus - Endometrium |
34 |
|
| Swiss/N | Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium |
21 |
||
| Swiss/N | Uterus lesion |
|
Uterus |
56 |
|
| Swiss/N | Uterus lesion |
|
Uterus |
49 |
|
| Swiss/N | Uterus lesion | Uterus |
41 |
||
| Swiss/N | Uterus neoplasm |
|
Uterus |
6.4 |
|
| Swiss/N | Uterus neoplasm |
|
Uterus |
13 |
|
| Swiss/N | Uterus neoplasm | Uterus |
11 |
||
| Swiss/N | (Unspecified organ) lymphohematopoietic neoplasm |
|
(Unspecified organ) |
17 - 33 |
|
| Swiss/N | (Unspecified organ) lymphohematopoietic neoplasm |
|
(Unspecified organ) |
12.5 - 25 |
|
| Swiss/N | (Unspecified organ) lymphohematopoietic neoplasm | (Unspecified organ) |
10 - 31 |
||
| Swiss/N | (Unspecified organ) neoplasm |
|
(Unspecified organ) |
9.3 |
|
| Swiss/N | (Unspecified organ) neoplasm |
|
(Unspecified organ) |
16 |
|
| Swiss/N | (Unspecified organ) neoplasm | (Unspecified organ) |
7.0 |
||
| Swiss/N | (Unspecified organ) neoplasm - unclassified |
|
(Unspecified organ) |
1.9 - 2.6 |
|
| Swiss/N | (Unspecified organ) neoplasm - unclassified |
|
(Unspecified organ) |
0 - 4.2 |
|
| Swiss/N | (Unspecified organ) neoplasm - unclassified | (Unspecified organ) |
1.4 - 2.1 |
||
| Swiss/N | (Unspecified organ) squamous cell carcinoma | (Unspecified organ) |
4.2 |
||
| Swiss/N | (Unspecified organ) squamous cell carcinoma |
|
(Unspecified organ) |
1.4 |
|
| Swiss/N | (Unspecified organ) tumor |
|
(Unspecified organ) |
15 |
|
| Swiss/N | (Unspecified organ) tumor |
|
(Unspecified organ) |
15 - 22 |
|
| Swiss/N | (Unspecified organ) tumor | (Unspecified organ) |
12.5 - 24 |