Reference SummaryWang TC, Nature 1994 Jun 23;369(6482):669-71

Title

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice.

Authors

Wang TC; Cardiff RD; Zukerberg L; Lees E; Arnold A; Schmidt EV

Journal

Nature

Volume

369

Issue

6482

Year

1994

Pages

669-71

Abstract

Physical associations between cyclins, viral oncogenes and tumour suppressor genes imply a central role for cyclins in growth control. Cyclin D1 was identified as a candidate oncogene (PRAD1) in tumour-specific DNA rearrangements and is suspected to be a contributor to several types of neoplasms including breast cancer. Cyclin D1 also rescues G1 cyclin-defective Saccharomyces cerevisiae, and is a growth-regulated gene. Despite evidence suggesting that cyclin D1 is an oncogene, its ability to transform cells directly in culture remains controversial. To evaluate its potential to deregulate growth in vivo in a physiologically relevant tissue we overexpressed cyclin D1 in mammary cells in transgenic mice. We report here that overexpression of cyclin D1 resulted in abnormal mammary cell proliferation including the development of mammary adenocarcinomas. We conclude that overexpression of cyclin D1 deregulates cell proliferation and can induce tumorigenic changes in mammary tissues, suggesting that cyclin D1 indeed plays an important oncogenic role in breast cancer.

Links

8208295 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
[not specified]-Tg(MMTV-CCND1)1Esmp Mammary gland adenoacanthoma Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)1Esmp Mammary gland adenocarcinoma Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)2Esmp Mammary gland adenocarcinoma Mammary gland

100

FVB Mammary gland adenocarcinoma Mammary gland

0

[not specified]-Tg(MMTV-CCND1)6Esmp Mammary gland adenocarcinoma - papillary Mammary gland

100

[not specified]-Tg(MMTV-CCND1)1Esmp Mammary gland hyperplasia Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)2Esmp Mammary gland hyperplasia Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)3Esmp Mammary gland hyperplasia Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)4Esmp Mammary gland hyperplasia Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)6Esmp Mammary gland hyperplasia Mammary gland

observed

[not specified]-Tg(MMTV-CCND1)1Esmp Mammary gland tumor Mammary gland

62.5

[not specified]-Tg(MMTV-CCND1)1Esmp Mesodermal cell/mesoblast sarcoma Uterus

12.5

[not specified]-Tg(MMTV-CCND1)1Esmp Mesodermal cell/mesoblast sarcoma Testis

100