Reference SummarySuwa T, Toxicol Pathol 2002 Mar-Apr;30(2):228-34
Title |
Spontaneous lesions in control B6C3F1 mice and recommended sectioning of male accessory sex organs. |
Authors |
Suwa T; Nyska A; Haseman JK; Mahler JF; Maronpot RR |
Journal |
Toxicol Pathol |
Volume |
30 |
Issue |
2 |
Year |
2002 |
Pages |
228-34 |
Abstract |
Because sampling of the paired lobes (ventral, dorsal, lateral, and anterior) of the mouse prostate has often been inconsistent, comparisons among different investigations have lacked validity. The absence of site identification for prostatic lesions has made reported incidences relatively nonspecific. We present here the lobe-specific incidences and degree of severity of spontaneous lesions in prostate, coagulating gland (anterior prostatic lobe), seminal vesicles, and ampullary glands in 612 control B6C3F1 mice from 12 recent National Toxicology Program 2-year carcinogenicity and toxicity studies conducted in 1 of 4 different laboratories. Lymphocytic infiltration, inflammation, epithelial hyperplasia, mucinous cyst, and mucinous metaplasia were observed in the dorsolateral lobes. Lymphocytic infiltration, inflammation, epithelial hyperplasia, and edema were present in the ventral lobes. Lymphocytic infiltration, acinar dilatation, inflammation, epithelial hyperplasia, and atrophy occurred in the coagulating glands. No neoplastic lesions were observed in the prostate or coagulating gland. Lymphocytic infiltration, acinar dilatation, inflammation, atrophy, adenoma, adenocarcinoma, and a granular cell tumor were observed in the seminal vesicles. Lymphocytic infiltration was also present in the ampullary glands. The results of our survey indicate that the amounts of glandular tissues were not present consistently in slides from the different laboratories. Landmarks for uniform tissue trimming are needed. We therefore suggest an optimal trimming and embedding method for mouse prostate and seminal vesicles to ensure adequate, consistent sampling. |
Links |
J:75741 – MGI References 11950166 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| (C57BL/6N x C3H/HeN)F1 | Adipose tissue liposarcoma | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland adenocarcinoma | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland adenoma | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland cyst - mucinous | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland lesion - neoplastic | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland metaplasia - mucinous | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland tumor | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Ampullary gland tumor - granular cell | Ampullary gland |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Blood vessel hemangiosarcoma | Prostate gland - Dorsolateral lobe |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte hyperplasia | Prostate gland - Dorsolateral lobe |
26.97 - 42.18 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte hyperplasia | Prostate gland - Anterior lobe |
10.08 - 26.03 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte hyperplasia | Prostate gland - Ventral lobe |
28.46 - 38.46 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte hyperplasia | Seminal vesicle |
10.74 - 27.78 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte hyperplasia | Ampullary gland |
0 - 10.42 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte lymphoma | Prostate gland - Dorsolateral lobe |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte lymphoma | Prostate gland - Anterior lobe |
0 - 2.74 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte lymphoma | Prostate gland - Ventral lobe |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte lymphoma | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Lymphocyte lymphoma | Ampullary gland |
0 - 9.09 |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Prostate gland - Dorsolateral lobe |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte leukemia | Prostate gland - Dorsolateral lobe |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte leukemia | Prostate gland - Ventral lobe |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Leukocyte leukemia | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Lung carcinoma - bronchioalveolar | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe adenocarcinoma | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe adenoma | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe cyst - mucinous | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe hyperplasia - epithelial | Prostate gland - Anterior lobe |
0 - 1.39 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe lesion - neoplastic | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe metaplasia - mucinous | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe tumor | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Anterior lobe tumor - granular cell | Prostate gland - Anterior lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe adenocarcinoma | Prostate gland - Dorsolateral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe adenoma | Prostate gland - Dorsolateral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe cyst - mucinous | Prostate gland - Dorsolateral lobe |
0 - 1.36 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe hyperplasia - epithelial | Prostate gland - Dorsolateral lobe |
0.66 - 1.37 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe lesion - neoplastic | Prostate gland - Dorsolateral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe metaplasia - mucinous | Prostate gland - Dorsolateral lobe |
0 - 0.68 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe tumor | Prostate gland - Dorsolateral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Dorsolateral lobe tumor - granular cell | Prostate gland - Dorsolateral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe adenocarcinoma | Prostate gland - Ventral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe adenoma | Prostate gland - Ventral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe cyst - mucinous | Prostate gland - Ventral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe hyperplasia - epithelial | Prostate gland - Ventral lobe |
0 - 2.54 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe lesion - neoplastic | Prostate gland - Ventral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe metaplasia - mucinous | Prostate gland - Ventral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Prostate gland - Ventral lobe tumor - granular cell | Prostate gland - Ventral lobe |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle adenocarcinoma | Seminal vesicle |
0 - 0.68 |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle adenoma | Seminal vesicle |
0 - 0.67 |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle cyst - mucinous | Seminal vesicle |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle lesion - neoplastic | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle metaplasia - mucinous | Seminal vesicle |
0 |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle tumor | Seminal vesicle |
0 - observed |
||
| (C57BL/6N x C3H/HeN)F1 | Seminal vesicle tumor - granular cell | Seminal vesicle |
0 - 0.62 |
||
| (C57BL/6N x C3H/HeN)F1 | (Unspecified organ) hyperplasia | Prostate gland - Anterior lobe |
0 - 2.74 |
||
| (C57BL/6N x C3H/HeN)F1 | (Unspecified organ) tumor | Prostate gland - Dorsolateral lobe |
0 - 2.83 |
||
| (C57BL/6N x C3H/HeN)F1 | (Unspecified organ) tumor | Prostate gland - Ventral lobe |
0 - 2.54 |
||
| (C57BL/6N x C3H/HeN)F1 | (Unspecified organ) tumor | Seminal vesicle |
0 - 2.7 |
||
| (C57BL/6N x C3H/HeN)F1 | (Unspecified organ) tumor | Ampullary gland |
0 - 9.09 |
||
| (C57BL/6N x C3H/HeN)F1 | (Unspecified organ) tumor | Prostate gland - Anterior lobe |
0.87 |