Reference SummaryFlemming A, Nat Immunol 2003 Jan;4(1):38-43
Title |
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. |
Authors |
Flemming A; Brummer T; Reth M; Jumaa H |
Journal |
Nat Immunol |
Volume |
4 |
Issue |
1 |
Year |
2003 |
Pages |
38-43 |
Abstract |
Mice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers of mature B cells, but an increased pre-B cell compartment. We show here that compared to wild-type cells, SLP-65(-/-) pre-B cells show an enhanced ex vivo proliferative capacity. This proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In addition, SLP-65(-/-) mice have a high incidence of pre-B cell lymphoma. Reintroduction of SLP-65 into SLP-65(-/-) pre-B cells led to pre-BCR down-regulation and enhanced differentiation. Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor. |
Links |
J:80332 – MGI References 12436112 – National Library of Medicine/PubMed |
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
BALB/c | Leukocyte - Lymphocyte - Pre-B-lymphocyte hyperplasia | Leukocyte - Lymphocyte - Pre-B-lymphocyte |
0 |
||
[not specified]-Blnktm1Pjln | Leukocyte - Lymphocyte - Pre-B-lymphocyte hyperplasia | Leukocyte - Lymphocyte - Pre-B-lymphocyte |
9.5 |
||
BALB/c | Leukocyte - Lymphocyte - Pre-B-lymphocyte tumor | Leukocyte - Lymphocyte - Pre-B-lymphocyte |
0.05 |
||
[not specified]-Blnktm1Pjln | Leukocyte - Lymphocyte - Pre-B-lymphocyte tumor | Leukocyte - Lymphocyte - Pre-B-lymphocyte |
6.7 |