Reference SummaryMajumder PK, Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7841-6
Title |
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model. |
Authors |
Majumder PK; Yeh JJ; George DJ; Febbo PG; Kum J; Xue Q; Bikoff R; Ma H; Kantoff PW; Golub TR; Loda M; Sellers WR |
Journal |
Proc Natl Acad Sci U S A |
Volume |
100 |
Issue |
13 |
Year |
2003 |
Pages |
7841-6 |
Abstract |
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an angiogenic signature that included three angiogenin family members, one of which was found elevated in the plasma of men with prostate cancer. Thus, the MPAKT model may be useful in studying the role of Akt in prostate epithelial cell transformation and in the discovery of molecular markers relevant to human disease. |
Links |
J:84509 – MGI References 12799464 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB-Tg(Pbsn-AKT1)9Wrs | Prostate gland - Anterior lobe prostatic intraepithelial neoplasia (PIN) | Prostate gland - Anterior lobe |
0 |
||
| FVB-Tg(Pbsn-AKT1)9Wrs | Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia (PIN) | Prostate gland - Dorsolateral lobe |
observed |
||
| FVB-Tg(Pbsn-AKT1)9Wrs | Prostate gland - Ventral lobe prostatic intraepithelial neoplasia (PIN) | Prostate gland - Ventral lobe |
observed |
||
| B6;129S1-Ptentm1Ppp/+ | Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland |
0 - observed |
||
| FVB-Tg(Pbsn-AKT1)9Wrs | Prostate gland tumor - malignant | Prostate gland |
observed |