Reference SummaryUmeda Y, J Occup Health 2004 Mar;46(2):87-99

Title

 Carcinogenicity and chronic toxicity in mice and rats administered vinyl acetate monomer in drinking water.

Authors

 Umeda Y; Matsumoto M; Yamazaki K; Ohnishi M; Arito H; Nagano K; Yamamoto S; Matsushima T

Journal

 J Occup Health

Volume

 46

Issue

 2

Year

 2004

Pages

 87-99

Abstract

 Carcinogenicity and chronic toxicity of vinyl acetate monomer (VA) were examined in male and female Crj:BDF1 mice and F344/DuCrj Rats. Groups of 50 mice and 50 rats of each sex were orally administered VA in drinking water containing 0, 400, 2,000 or 10,000 ppm (g/g) VA for 104 wk. Squamous cell tumors were clearly evident in the upper digestive tract of treated mice and rats, and in the larynx of treated mice of both sexes. In mice, squamous cell carcinomas and papillomas were observed in the oral cavity, esophagus, forestomach and larynx of the 10,000 ppm group, together with basal cell hyperplasia, squamous cell hyperplasia and epithelial dysplasia. In rats, incidences of squamous cell carcinomas and papillomas were increased in the oral cavity of the 10,000 ppm group of both sexes, and an esophagus squamous cell carcinoma was observed in a 10,000 ppm female. Pre-neoplastic hyperplasias were also noted. Mapping of the neoplastic and pre-neoplastic lesions in the oral cavity of the 10,000 ppm group revealed that both the lesions occurred predominantly at Level V in mice and at Level VI in rats. A lower confidence limit of a benchmark dose (BMDL10) of 477 mg/kg/d was obtained from a dose-response relationship between combined incidence of squamous cell carcinomas and papillomas in the oral cavity of mice and rats and the estimated daily VA intakes per body weight, and compared with literature values.

Links

 J:90187 – MGI References
15090683 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6NCrlj x DBA/2NCrlj)F1 Blood vessel hemangiosarcoma Liver

6 - 8
(C57BL/6NCrlj x DBA/2NCrlj)F1 Blood vessel hemangiosarcoma Spleen

2 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Blood vessel hemangiosarcoma
  • vinyl acetate (VA)
 Liver

0 - 10
(C57BL/6NCrlj x DBA/2NCrlj)F1 Blood vessel hemangiosarcoma
  • vinyl acetate (VA)
 Spleen

0 - 8
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Mandible dysplasia - epithelial
  • vinyl acetate (VA)
 Bone - Jaw - Mandible

8.57 - 44.19
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Mandible hyperplasia - basal cell
  • vinyl acetate (VA)
 Bone - Jaw - Mandible

0 - 41.86
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Mandible hyperplasia - squamous
  • vinyl acetate (VA)
 Bone - Jaw - Mandible

8.57 - 23.26
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Mandible lesion
  • vinyl acetate (VA)
 Bone - Jaw - Mandible

6 - 10
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Mandible squamous cell carcinoma
  • vinyl acetate (VA)
 Bone - Jaw - Mandible

0 - 31.43
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Mandible squamous cell papilloma
  • vinyl acetate (VA)
 Bone - Jaw - Mandible

0 - 6.98
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Maxilla dysplasia - epithelial
  • vinyl acetate (VA)
 Bone - Jaw - Maxilla

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Maxilla hyperplasia - basal cell
  • vinyl acetate (VA)
 Bone - Jaw - Maxilla

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Maxilla hyperplasia - squamous
  • vinyl acetate (VA)
 Bone - Jaw - Maxilla

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Maxilla lesion
  • vinyl acetate (VA)
 Bone - Jaw - Maxilla

2 - 6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Maxilla squamous cell carcinoma
  • vinyl acetate (VA)
 Bone - Jaw - Maxilla

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Bone - Jaw - Maxilla squamous cell papilloma
  • vinyl acetate (VA)
 Bone - Jaw - Maxilla

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus dysplasia - epithelial Esophagus

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus dysplasia - epithelial
  • vinyl acetate (VA)
 Esophagus

0 - 14
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus hyperplasia - basal cell Esophagus

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus hyperplasia - basal cell
  • vinyl acetate (VA)
 Esophagus

0 - 30
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus hyperplasia - squamous Esophagus

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus hyperplasia - squamous
  • vinyl acetate (VA)
 Esophagus

0 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus preneoplastic lesion Esophagus

0 - observed
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus squamous cell carcinoma Esophagus

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus squamous cell carcinoma
  • vinyl acetate (VA)
 Esophagus

0 - 14
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus squamous cell papilloma Esophagus

0 - 0.1
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus squamous cell papilloma
  • vinyl acetate (VA)
 Esophagus

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Esophagus tumor
  • vinyl acetate (VA)
 Esophagus

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach dysplasia - epithelial Forestomach

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach dysplasia - epithelial
  • vinyl acetate (VA)
 Forestomach

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach hyperplasia - basal cell Forestomach

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach hyperplasia - basal cell
  • vinyl acetate (VA)
 Forestomach

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach hyperplasia - squamous Forestomach

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach hyperplasia - squamous
  • vinyl acetate (VA)
 Forestomach

0 - 8
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach preneoplastic lesion Forestomach

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach preneoplastic lesion
  • vinyl acetate (VA)
 Forestomach

0 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach squamous cell carcinoma Forestomach

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach squamous cell carcinoma
  • vinyl acetate (VA)
 Forestomach

0 - 14
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach squamous cell papilloma Forestomach

0 - 0.4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach squamous cell papilloma
  • vinyl acetate (VA)
 Forestomach

0 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach tumor - squamous Forestomach

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Forestomach tumor - squamous
  • vinyl acetate (VA)
 Forestomach

0 - 18
(C57BL/6NCrlj x DBA/2NCrlj)F1 Gingiva dysplasia - epithelial
  • vinyl acetate (VA)
 Gingiva

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Gingiva hyperplasia - basal cell
  • vinyl acetate (VA)
 Gingiva

2.86 - 9.09
(C57BL/6NCrlj x DBA/2NCrlj)F1 Gingiva hyperplasia - squamous
  • vinyl acetate (VA)
 Gingiva

0 - 2.27
(C57BL/6NCrlj x DBA/2NCrlj)F1 Gingiva squamous cell carcinoma
  • vinyl acetate (VA)
 Gingiva

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Gingiva squamous cell papilloma
  • vinyl acetate (VA)
 Gingiva

0 - 2.86
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx dysplasia - epithelial Larynx

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx dysplasia - epithelial
  • vinyl acetate (VA)
 Larynx

0 - 6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx hyperplasia - basal cell Larynx

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx hyperplasia - basal cell
  • vinyl acetate (VA)
 Larynx

0 - 12
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx hyperplasia - squamous Larynx

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx hyperplasia - squamous
  • vinyl acetate (VA)
 Larynx

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx preneoplastic lesion Larynx

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx preneoplastic lesion
  • vinyl acetate (VA)
 Larynx

0 - observed
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx squamous cell carcinoma Larynx

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx squamous cell carcinoma
  • vinyl acetate (VA)
 Larynx

0 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Larynx tumor
  • vinyl acetate (VA)
 Larynx

2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Nose - Nasal cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • vinyl acetate (VA)
 Nose - Nasal cavity

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus

20
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • vinyl acetate (VA)
 Uterus

16 - 22
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte lymphoma Spleen

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte lymphoma
  • vinyl acetate (VA)
 Spleen

0 - 10
(C57BL/6NCrlj x DBA/2NCrlj)F1 Liver hepatocellular adenoma Liver

4 - 6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Liver hepatocellular adenoma
  • vinyl acetate (VA)
 Liver

0 - 12
(C57BL/6NCrlj x DBA/2NCrlj)F1 Liver hepatocellular carcinoma Liver

2 - 26
(C57BL/6NCrlj x DBA/2NCrlj)F1 Liver hepatocellular carcinoma
  • vinyl acetate (VA)
 Liver

0 - 20
(C57BL/6NCrlj x DBA/2NCrlj)F1 Lung adenoma Lung

2 - 6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Lung adenoma
  • vinyl acetate (VA)
 Lung

2 - 8
(C57BL/6NCrlj x DBA/2NCrlj)F1 Lung carcinoma Lung

4 - 14
(C57BL/6NCrlj x DBA/2NCrlj)F1 Lung carcinoma
  • vinyl acetate (VA)
 Lung

2 - 10
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Lip dysplasia - epithelial
  • vinyl acetate (VA)
 Mouth - Lip

6.82 - 8.57
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Lip hyperplasia - basal cell
  • vinyl acetate (VA)
 Mouth - Lip

9.09 - 22.86
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Lip hyperplasia - squamous
  • vinyl acetate (VA)
 Mouth - Lip

0 - 9.09
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Lip squamous cell carcinoma
  • vinyl acetate (VA)
 Mouth - Lip

2.27 - 5.71
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Lip squamous cell papilloma
  • vinyl acetate (VA)
 Mouth - Lip

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Oral mucosa dysplasia - epithelial
  • vinyl acetate (VA)
 Mouth - Oral mucosa

2.04 - 10
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Oral mucosa hyperplasia - basal cell
  • vinyl acetate (VA)
 Mouth - Oral mucosa

2 - 12.24
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Oral mucosa hyperplasia - squamous
  • vinyl acetate (VA)
 Mouth - Oral mucosa

0 - 6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Oral mucosa squamous cell carcinoma
  • vinyl acetate (VA)
 Mouth - Oral mucosa

0 - 6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Oral mucosa squamous cell papilloma
  • vinyl acetate (VA)
 Mouth - Oral mucosa

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Palate dysplasia - epithelial
  • vinyl acetate (VA)
 Mouth - Palate

0 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Palate hyperplasia - basal cell
  • vinyl acetate (VA)
 Mouth - Palate

0 - 2.04
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Palate hyperplasia - squamous
  • vinyl acetate (VA)
 Mouth - Palate

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Palate squamous cell carcinoma
  • vinyl acetate (VA)
 Mouth - Palate

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mouth - Palate squamous cell papilloma
  • vinyl acetate (VA)
 Mouth - Palate

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity dysplasia - epithelial Oral cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity dysplasia - epithelial
  • vinyl acetate (VA)
 Oral cavity

0 - 48
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity hyperplasia - basal cell Oral cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity hyperplasia - basal cell
  • vinyl acetate (VA)
 Oral cavity

0 - 36
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity hyperplasia - squamous Oral cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity hyperplasia - squamous
  • vinyl acetate (VA)
 Oral cavity

0 - 26
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity lesion
  • vinyl acetate (VA)
 Oral cavity

6 - 10
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity preneoplastic lesion Oral cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity preneoplastic lesion
  • vinyl acetate (VA)
 Oral cavity

0 - observed
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity squamous cell carcinoma
  • vinyl acetate (VA)
 Oral cavity

0 - 30
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity squamous cell carcinoma Oral cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity squamous cell papilloma Oral cavity

0 - 0.1
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity squamous cell papilloma
  • vinyl acetate (VA)
 Oral cavity

0 - 8
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity tumor
  • vinyl acetate (VA)
 Oral cavity

8 - 12
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity tumor - malignant
  • vinyl acetate (VA)
 Oral cavity

observed
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity tumor - squamous Oral cavity

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Oral cavity tumor - squamous
  • vinyl acetate (VA)
 Oral cavity

0 - 36
(C57BL/6NCrlj x DBA/2NCrlj)F1 Stomach tumor
  • vinyl acetate (VA)
 Stomach

2 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Tongue squamous cell carcinoma Tongue

0 - 4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Tongue squamous cell carcinoma
  • vinyl acetate (VA)
 Tongue

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Tongue squamous cell papilloma Tongue

0 - 0.1
(C57BL/6NCrlj x DBA/2NCrlj)F1 Tongue squamous cell papilloma
  • vinyl acetate (VA)
 Tongue

0 - 2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma

0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Uterus - Endometrium - Stroma polyp
  • vinyl acetate (VA)
 Uterus - Endometrium - Stroma

0 - 2