Reference SummaryAnisimov VN, Int J Cancer 2004 Sep 10;111(4):475-9

Title

Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice.

Authors

Anisimov VN; Baturin DA; Popovich IG; Zabezhinski MA; Manton KG; Semenchenko AV; Yashin AI

Journal

Int J Cancer

Volume

111

Issue

4

Year

2004

Pages

475-9

Abstract

The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age of 2 months were kept under standard light/dark regimen (12 hr light:12hr dark; LD) and 50 CBA mice of similar age were kept under constant illumination (24 hr a day, 2,500 Lux, LL). Exposure to the LL regimen decreased food consumption but did not influence body weight, significantly accelerated age-related disturbances in estrous function, and was followed by a significant increase in spontaneous tumor incidence in female CBA mice. Tumor incidence as well as the number of total or malignant tumors was significantly increased in the LL group compared to the LD group (p < 0.001). The incidence of lung adenocarcinomas, leukemias and hepatocarcinomas was 7/50; 6/50 and 4/50 in the LL group and 1/50; 0/50 and 0/50 in the LD group. Mice from the LL groups had shorter life spans then those from the LD group. The data demonstrate, for the first time, that exposure to constant illumination was followed by increases in the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice.

Links

15239122 – National Library of Medicine/PubMed

Strain Notes

Strain Note
CBA/Rap Mice reported in this reference were "purchased from the 'Rappolovo' Animal Farm of the Russian Academy of Medical Sciences."

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
CBA/Rap Blood vessel hemangioma Liver

0

CBA/Rap Blood vessel hemangioma
  • constant light
Liver

2.0

CBA/Rap Forestomach papilloma Forestomach

0

CBA/Rap Forestomach papilloma
  • constant light
Forestomach

2.0

CBA/Rap Leukocyte leukemia Leukocyte

0

CBA/Rap Leukocyte leukemia
  • constant light
Leukocyte

12

CBA/Rap Liver hepatocellular carcinoma Liver

0

CBA/Rap Liver hepatocellular carcinoma
  • constant light
Liver

8.0

CBA/Rap Lung adenocarcinoma Lung

2.0

CBA/Rap Lung adenocarcinoma
  • constant light
Lung

14

CBA/Rap Lung adenoma Lung

2.0

CBA/Rap Lung adenoma
  • constant light
Lung

2.0

CBA/Rap Mammary gland adenocarcinoma Mammary gland

2.0

CBA/Rap Mammary gland adenocarcinoma
  • constant light
Mammary gland

4.0

CBA/Rap Mesodermal cell/mesoblast sarcoma - histiocytic fibrous Mesodermal cell/mesoblast

2.0

CBA/Rap Mesodermal cell/mesoblast sarcoma - histiocytic fibrous
  • constant light
Mesodermal cell/mesoblast

0

CBA/Rap Skin - Epidermis - Basal cell carcinoma Skin - Epidermis - Basal cell

2.0

CBA/Rap Skin - Epidermis - Basal cell carcinoma
  • constant light
Skin - Epidermis - Basal cell

0

CBA/Rap (Unspecified organ) tumor (Unspecified organ)

8.0

CBA/Rap (Unspecified organ) tumor
  • constant light
(Unspecified organ)

30