Strain SummaryC57BL/6-Krastm4Tyj/+ Ptf1atm1.1(cre)Cvw/+
Strain Name |
C57BL/6-Krastm4Tyj/+ Ptf1atm1.1(cre)Cvw/+ |
Strain Type(s) |
targeted mutation (conditional) • targeted mutation (knock-in) |
Strain Synonym(s) |
LSL-KrasG12D;p48-Cre;Sag+/+ • KC |
Description |
Heterozygous Kras, Ptf1a mice on a C57BL/6 background with contribution from 129/SvJae, 129X1/SvJ, and 129S1/Sv. All mice were back-crossed more than 6 times to C57BL/6 background. |
Strain Genetics |
Ptf1atm1.1(cre)Cvw / Ptf1a+ |
Krastm4Tyj / Kras+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Pancreas - Acinar cell metaplasia - ductal | Pancreas - Acinar cell |
observed |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
||||
Pancreas adenocarcinoma - ductal | Pancreas |
observed |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
||||
Pancreas hyperplasia | Pancreas |
observed |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
||||
Pancreas lesion - cystic | Pancreas |
observed |
0 - 10 |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
||||
Pancreas pancreatic intraepithelial neoplasia 1 (PanIN1) | Pancreas |
observed |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
||||
Pancreas pancreatic intraepithelial neoplasia 2 (PanIN2) | Pancreas |
observed |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
||||
Pancreas pancreatic intraepithelial neoplasia 2 (PanIN2) | PNS - Schwann cell |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
|||||
Pancreas pancreatic intraepithelial neoplasia 3 (PanIN3) | Pancreas |
observed |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |