Strain SummaryC57BL/6-Krastm4Tyj/+ Ptf1atm1.1(cre)Cvw/+ Shoc2tm1.1Mhan Rnf7tm1.1Ysun
Strain Name |
C57BL/6-Krastm4Tyj/+ Ptf1atm1.1(cre)Cvw/+ Shoc2tm1.1Mhan Rnf7tm1.1Ysun |
Strain Type(s) |
targeted mutation (conditional) • targeted mutation (knock-in) |
Strain Synonym(s) |
LSL-KrasG12D;p48-Cre;Sagfl/fl; Shoc2fl/fl • KC-Sag/Shoc |
Description |
Heterozygous Kras, Ptf1a, homozygous Rnf7, Shoc2 mice on a C57BL/6 background with contribution from 129/SvJae, 129X1/SvJ, 129S1/Sv and 129S6/SvEvTac. All mice were back-crossed more than 6 times to C57BL/6 background. |
Strain Genetics |
Ptf1atm1.1(cre)Cvw / Ptf1a+ |
Rnf7tm1.1Ysun / Rnf7tm1.1Ysun | |
Shoc2tm1.1Mhan / Shoc2tm1.1Mhan | |
Krastm4Tyj / Kras+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Pancreas adenocarcinoma - ductal | Pancreas |
0 |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
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Pancreas lesion - cystic | Pancreas |
0 |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
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Pancreas pancreatic intraepithelial neoplasia 1 (PanIN1) | Pancreas |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
|||||
Pancreas pancreatic intraepithelial neoplasia 2 (PanIN2) | Pancreas |
observed |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |
|||||
Pancreas pancreatic intraepithelial neoplasia 3 (PanIN3) | Pancreas |
0 |
References: Tan M, Cell Rep 2022 Dec 20;41(12):111837 |