Strain SummaryC57BL/6-Ccr2tm1Ifc Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+

Strain Name

 C57BL/6-Ccr2tm1Ifc Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+

Strain Type(s)

 targeted mutation (conditional)  •  targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

 KPC-CCR2?/?

Description

 Homozygous Ccr2, heterozygous Kras, Trp53 mice carrying the transgene on a C57BL/6 background with contribution from 129S4, 129S4/SvJae, and FVB/N.

Models

18 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas adenocarcinoma - ductal Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas adenocarcinoma - poorly differentiated Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas adenocarcinoma - well-differentiated Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas carcinoma Pancreas gemcitabine

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas carcinoma Pancreas anti-CTLA4 antibody   ⋅   gemcitabine   ⋅   anti-PD1 antibody

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas carcinoma Pancreas CCR2 inhibitor (CCX598)   ⋅   anti-CTLA4 antibody   ⋅   gemcitabine   ⋅   anti-PD1 antibody

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas carcinoma Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas pancreatic intraepithelial neoplasia (PanIN) Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas pancreatic intraepithelial neoplasia (PanIN) - low grade Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Sites of Metastasis: Liver , Lung , Muscle - Striated - Skeletal - Diaphragm
Pancreas tumor (Unspecified organ)

40

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Liver

26

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Lung

32

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Muscle - Striated - Skeletal - Diaphragm

21

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Lymph node

79

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Spleen

5 - 41

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Abdominal wall

0

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Intestine

21

References: Dixit A, JCI Insight 2022 Nov 22;7(22):