Strain SummaryC57BL/6-Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+

Strain Name

 C57BL/6-Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+

Strain Type(s)

 targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

 KPC

Description

 Homozygous Ccr2, heterozygous Kras, Trp53 mice carrying the transgene on a C57BL/6 background with contribution from 129S4, 129S4/SvJae, and FVB/N.

Models

19 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas adenocarcinoma - ductal Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Sites of Metastasis: Liver
Pancreas adenocarcinoma - ductal Pancreas gemcitabine

100

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Sites of Metastasis: (Unspecified organ) , not Abdominal wall , not Kidney , Gallbladder , Intestine , Liver , Lung , Lymph node , Muscle - Striated - Skeletal - Diaphragm , Peritoneum - Mesentery , Pleural cavity , Spleen , Stomach
Pancreas adenocarcinoma - ductal Pancreas anti-CTLA4 antibody   ⋅   gemcitabine   ⋅   anti-PD1 antibody

100

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Sites of Metastasis: (Unspecified organ) , not Abdominal wall , not Kidney , not Peritoneum - Mesentery , not Stomach , Gallbladder , Intestine , Liver , Lymph node , Muscle - Striated - Skeletal - Diaphragm , Pleural cavity , Spleen
Pancreas adenocarcinoma - ductal Pancreas CCR2 inhibitor (CCX598)   ⋅   anti-CTLA4 antibody   ⋅   gemcitabine   ⋅   anti-PD1 antibody

100

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Sites of Metastasis: (Unspecified organ) , not Kidney , not Peritoneum - Mesentery , not Spleen , Abdominal wall , Gallbladder , Intestine , Liver , Lung , Lymph node , Muscle - Striated - Skeletal - Diaphragm , Pleural cavity , Stomach
Pancreas adenocarcinoma - moderately differentiated Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas adenocarcinoma - poorly differentiated Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas adenocarcinoma - well-differentiated Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas pancreatic intraepithelial neoplasia (PanIN) Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas pancreatic intraepithelial neoplasia (PanIN) - high grade Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas pancreatic intraepithelial neoplasia (PanIN) - low grade Pancreas

observed

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Pancreas

observed - 86

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Sites of Metastasis: (Unspecified organ) , Liver , Lung , Muscle - Striated - Skeletal - Diaphragm
Pancreas tumor Liver

55

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Lung

41

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Muscle - Striated - Skeletal - Diaphragm

37

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Lymph node

77

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Spleen

14 - 55

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Gallbladder

23

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Abdominal wall

5

References: Dixit A, JCI Insight 2022 Nov 22;7(22):

Pancreas tumor Intestine

23

References: Dixit A, JCI Insight 2022 Nov 22;7(22):