Strain SummaryB6.129S7-Trp53tm1Brd/+

Strain Name

 B6.129S7-Trp53tm1Brd/+

Strain Type(s)

 congenic  •  targeted mutation (knockout)

Strain Synonym(s)

 C57BL/6-Trp53tm1Bay/+  •  heterozygote p53 knockout  •  p53(+/-)  •  p53+/-  •  Trp53+/-  •  p53+/-  •  p53-deficient  •  p53 heterozygous  •  TGS-p53tm  •  TSG-p53(+/-)

Description

 Heterozygous mice. These mice had been backcrossed to C57BL/6. The targeted mutation was generated in 129S7/SvEvBrd-Hprt+-derived ES cells.

Strain Genetics

 Trp53tm1Brd / Trp53+

Models

29 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Blood vessel hemangioma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

23 - 42

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Blood vessel hemangiosarcoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

7.7 - 17

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Bone osteosarcoma Bone

8.8

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

6.1

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Germ cell (sex not specified) teratocarcinoma Germ cell (sex not specified)

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Leukocyte lymphoma Leukocyte

8.2 - 10

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Leukocyte lymphoma Thymus

2.0

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Liver carcinoma Liver

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

16

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Salivary gland carcinoma Salivary gland

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Skin carcinoma Skin

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Skin papilloma Skin

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Testis tumor - cystic Testis

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Urinary bladder dysplasia Urinary bladder p-cresidine

high

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder dysplasia Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

46 - 100

100

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder hyperplasia Urinary bladder p-cresidine

high

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder hyperplasia Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

observed

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder squamous cell carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

0 - 50

20

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder transitional cell carcinoma Urinary bladder p-cresidine

40 - 100.0

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder transitional cell carcinoma Urinary bladder calorie restricted   ⋅   p-cresidine

0

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder transitional cell carcinoma Urinary bladder calorie restricted   ⋅   insulin-like growth factor 1 - human recombinant (IGF-1)   ⋅   p-cresidine

60

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder transitional cell carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

0 - 100

60

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder transitional cell carcinoma in situ Urinary bladder p-cresidine

0

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder transitional cell carcinoma in situ Urinary bladder calorie restricted   ⋅   p-cresidine

20

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder transitional cell carcinoma in situ Urinary bladder calorie restricted   ⋅   insulin-like growth factor 1 - human recombinant (IGF-1)   ⋅   p-cresidine

0

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72

Urinary bladder tumor Urinary bladder

0

References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72   ⋅   Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

(Unspecified organ) adenocarcinoma (Unspecified organ)

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

(Unspecified organ) angiosarcoma (Unspecified organ)

0.7

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

(Unspecified organ) tumor (Unspecified organ)

31 - 72

References: Nister M, Oncogene 2005 May 19;24(22):3563-73