Strain SummaryC57BL/6J +/+ : 129S1/Sv p+ Tyr+ Kitl+ Ptentm1Rps/+
Strain Name |
C57BL/6J +/+ : 129S1/Sv p+ Tyr+ Kitl+ Ptentm1Rps/+ |
Strain Type(s) |
chimeric • targeted mutation (knockout) |
Strain Synonym(s) |
129SvJ/C57B6 chimera • Pten+/- chimera |
Description |
Chimeric mice generated by injection of gene-targeted W9.5 ES cells into wild-type C57BL/6J blastocysts. The ES cells were heterozygous for a targeted mutation of the Pten gene, Ptentm1Rps. |
Strain Genetics |
Ptentm1Rps / Pten+ |
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Frequency | ||||||||
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Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Intestine - Large Intestine polyp | Intestine - Large Intestine |
89 |
References: Podsypanina K, Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8 3 pathology image(s) |
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Intestine - Small Intestine polyp | Intestine - Small Intestine |
89 |
References: Podsypanina K, Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8 2 pathology image(s) |
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Testis - Germ cell teratoma | Testis - Germ cell |
11 |
References: Podsypanina K, Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8 |