Strain SummarySTOCK Cdkn2atm1Rdp Tg(Tyr-HRAS)60Lc
Strain Name |
STOCK Cdkn2atm1Rdp Tg(Tyr-HRAS)60Lc |
Strain Type(s) |
targeted mutation (knockout) • transgenic |
Strain Synonym(s) |
ink4a-/- transgenic • Tyr-H-Ras(G12V) Ink4a/Arf-/- • tyr-ras ink4a-/- • STOCK Tg(Tyr-HRAS)60Lc Cdkn2atm1Rdp • TR60 ink4a-/- • TRIA |
Description |
Mice were homozygous for the Cdkn2a mutant allele and carried the transgene. This STOCK genetic background was a mixture of C57BL/6J, CBA/J, "129/Sv" (substrain unspecified), and SJL/J. |
Strain Genetics |
Tg(Tyr-HRAS)60Lc |
| Cdkn2atm1Rdp / Cdkn2atm1Rdp |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
18 |
References: Chin L, Genes Dev 1997 Nov 1;11(21):2822-34 |
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| Skin - Melanocyte melanoma | Skin - Melanocyte |
observed - 81 |
References: Chin L, Genes Dev 1997 Nov 1;11(21):2822-34 ⋅ Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
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| Skin - Melanocyte melanoma | Skin - Melanocyte | ionizing radiation |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | lonafarnib |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | carboplatin |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | Taxol (paclitaxel) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | carboplatin ⋅ Taxol (paclitaxel) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | veliparib (ABT-888) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | veliparib (ABT-888) ⋅ carboplatin |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | temozolomide (TMZ) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | veliparib (ABT-888) ⋅ temozolomide (TMZ) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | erlotinib |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | lapatinib |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | sunitinib |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | salirasib (farnesylthiosalicylic acid) (FTS) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | selumetinib (AZD6244) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | BEZ235 (NVP-BEZ235-AN) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
||||
| Skin - Melanocyte melanoma | Skin - Melanocyte | selumetinib (AZD6244) ⋅ BEZ235 (NVP-BEZ235-AN) |
observed |
References: Roberts PJ, Clin Cancer Res 2012 Oct 1;18(19):5290-303 |
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