Strain SummaryB6;129-Cdkn2a^tm1Cjs Rb1^tm1Tyj/+

Strain Name	B6;129-Cdkn2a^tm1Cjs Rb1^tm1Tyj/+
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	Rb+/-;ARF-/-
Description	Mice were homozygous for Cdkn2a^tm1Cjs and heterozygous for Rb1^tm1Tyj. The genetic background of these mice is referred to as 129 X C57BL/6 and involves C57BL/6, 129S2/SvPas, and 129X1/SvJ.
Strain Genetics	List all models in MMHCdb carrying the Rb1^tm1Tyj allele Rb1^tm1Tyj / Rb1⁺
	List all models in MMHCdb carrying the Cdkn2a^tm1Cjs allele Cdkn2a^tm1Cjs / Cdkn2a^tm1Cjs

Models
6 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Lung hyperplasia	Lung					0	References: Tsai KY, Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16865-70
Pancreas - Islet of Langerhans hyperplasia	Pancreas - Islet of Langerhans					0	References: Tsai KY, Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16865-70
Pineal gland pineoblastoma	Pineal gland					0	References: Tsai KY, Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16865-70
Pituitary gland - Pars intermedia tumor	Pituitary gland - Pars intermedia					very high	References: Tsai KY, Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16865-70 2 pathology image(s)
Pituitary gland lesion	Pituitary gland					25 - 100	References: Tsai KY, Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16865-70 3 pathology image(s)
Thyroid gland - Medulla - C cell carcinoma	Thyroid gland - Medulla - C cell					high	References: Tsai KY, Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16865-70

Models