Strain SummaryB6;129-Trp53tm1Brd

Strain Name

 B6;129-Trp53tm1Brd

Strain Type(s)

 targeted mutation (knockout)

Strain Synonym(s)

 C57B6/129Sv (-/-)  •  C57B6/129Sv mixed p53 null (-/-)  •  TSG-p53-/-  •  p53-deficient  •  p53 null (-/-)  •  p53-/-  •  TSG-p53  •  TSG-p53-null

Description

 Homozygous mice. The genetic background of these mice was a mixture of C57BL/6 and "129/Sv" (substrain not specified but included at least some 129S7/SvEvBrd-Hprt1+). These mice were from Taconic.

Strain Genetics

 Trp53tm1Brd / Trp53tm1Brd

Models

17 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Blood vessel hemangiosarcoma Blood vessel

4.35

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Bone osteosarcoma Bone

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

CNS - Brain - Astrocyte astrocytoma - anaplastic CNS - Brain - Astrocyte

4.35

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

CNS - Brain glioma CNS - Brain Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb   ⋅   Moloney Murine Leukemia helper virus

observed

References: Johansson FK, Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11334-7

CNS - Brain tumor CNS - Brain Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb

89.47

References: Hesselager G, Cancer Res 2003 Aug 1;63(15):4305-9

CNS - Brain tumor CNS - Brain MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)

0

References: Hesselager G, Cancer Res 2003 Aug 1;63(15):4305-9

CNS - Meninges meningioma CNS - Meninges

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Germ cell (sex not specified) teratoma Germ cell (sex not specified)

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Intestine - Small Intestine tumor Intestine - Small Intestine

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Leukocyte lymphoma - non-Hodgkin Leukocyte

91

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Sites of Metastasis: not Seminal vesicle , Adrenal gland , Bone marrow , CNS - Meninges , Heart , Kidney , Liver , Lung , Lymph node , Ovary , Pancreas , Salivary gland , Spleen , Testis , Thymus
Leukocyte lymphoma - non-Hodgkin Thymus

26

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Leukocyte lymphoma - non-Hodgkin Spleen

52

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Leukocyte lymphoma - non-Hodgkin Lymph node

13

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

8.7

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Prostate gland tumor Prostate gland

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

(Unspecified organ) tumor - undifferentiated (Unspecified organ)

4.35

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22