Strain Summary[not specified]-Krastm4Tyj/+ Tg(CAG-Bgeo/GFP)21Lbe Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+
Strain Name |
[not specified]-Krastm4Tyj/+ Tg(CAG-Bgeo/GFP)21Lbe Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+ |
Strain Type(s) |
targeted mutation (conditional) • transgenic |
Strain Synonym(s) |
KPC • [not specified]-Krastm4Tyj/+ Tg(CAG-Bgeo/GFP)21Lbe Tg(Ipf1-cre)1Tuv Trp53tm2Tyj/+ • [not specified]-Krastm4Tyj/+ Tg(CAG-Bgeo/GFP)21Lbe Tg(Ipf1-cre)6Tuv Trp53tm2Tyj/+ • [not specified]-Krastm4Tyj/+ Tg(CAG-Bgeo/GFP)21Lbe Tg(Pdx1-cre)6Tuv Trp53tm2Tyj/+ • Pdx1-Cre-GFP, LSL-KrasG12D/+, LSL-Trp53R172H/+ |
Description |
Background was not specified with contributions from FVB/N and multiple 129 substrains. Mice were heterozygous for Krastm4Tyj and Trp53tm2Tyj and carried the Tg(Pdx1-cre)6Tuv and Tg(CAG-Bgeo/GFP)21Lbe transgenes. |
Strain Genetics |
Tg(CAG-Bgeo/GFP)21Lbe |
Tg(Pdx1-cre)6Tuv | |
Trp53tm2Tyj / Trp53+ | |
Krastm4Tyj / Kras+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Pancreas - Duct pancreatic intraepithelial neoplasia (PanIN) | Pancreas - Duct |
observed |
References: Morton JP, Proc Natl Acad Sci U S A 2010 Jan 5;107(1):246-51 7 pathology image(s) |
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Pancreas adenocarcinoma - ductal | Pancreas |
observed - 77.78 |
References: Morton JP, Proc Natl Acad Sci U S A 2010 Jan 5;107(1):246-51 Sites of Metastasis: Liver 17 pathology image(s) |