Strain Summary[not specified]-Brca2^tm1Brn Tg(Pbsn-cre)4Prb Trp53^tm1Brn

Strain Name	[not specified]-Brca2^tm1Brn Tg(Pbsn-cre)4Prb Trp53^tm1Brn
Strain Type(s)	targeted mutation (conditional) • transgenic
Strain Synonym(s)	Brca2^F/F;Trp53^F/F;PBCre4 • Brca2;Trp53 homozygous mutant
Description	Compound mutant mice. The genetic background of these mice was described as a "mixed genetic background" without the involved strains being specified. It included at least some 129P2/OlaHsd and some C57BL/6 and/or DBA/2.
Strain Genetics	List all models in MMHCdb carrying the Brca2^tm1Brn allele Brca2^tm1Brn / Brca2^tm1Brn
	List all models in MMHCdb carrying the Tg(Pbsn-cre)4Prb allele Tg(Pbsn-cre)4Prb
	List all models in MMHCdb carrying the Trp53^tm1Brn allele Trp53^tm1Brn / Trp53^tm1Brn

Models
5 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Prostate gland carcinoma	Prostate gland			0			References: Francis JC, PLoS Genet 2010;6(6):e1000995
Prostate gland hyperplasia	Prostate gland			67 - 94			References: Francis JC, PLoS Genet 2010;6(6):e1000995 1 pathology image(s)
Prostate gland prostatic intraepithelial neoplasia - high grade (HGPIN)	Prostate gland			0 - 84			References: Francis JC, PLoS Genet 2010;6(6):e1000995 8 pathology image(s)
Prostate gland prostatic intraepithelial neoplasia - high grade (HGPIN)	Prostate gland	castration		observed			References: Francis JC, PLoS Genet 2010;6(6):e1000995 4 pathology image(s)
Prostate gland prostatic intraepithelial neoplasia - low grade (LGPIN)	Prostate gland			0 - 91			References: Francis JC, PLoS Genet 2010;6(6):e1000995

Models