Strain SummarySTOCK Nkx3-1^{tm4(cre/ERT2)Mms}/+ Pten^tm1Hwu

Strain Name	STOCK Nkx3-1^{tm4(cre/ERT2)Mms}/+ Pten^tm1Hwu
Strain Type(s)	targeted mutation (conditional) • targeted mutation (knock-in)
Strain Synonym(s)	Nkx3.1^CE2/+; Pten^f/f • Nkx3.1^CreERT2/+; Pten^flox/flox • Nkx3.1^CreERT2/+; Pten^flox/flox; Kras^+/+* • Nkx3.1^CreERT2/+; Pten^flox/flox; Kras^+/+ • NP*
Description	Compound mutant mice. This STOCK genetic background included C57BL/6, "129/Sv" (including 129S6/SvEvTac and 129S4/SvJae), and FVB.
Strain Genetics	Kras⁺ / Kras⁺
	List all models in MMHCdb carrying the Pten^tm1Hwu allele Pten^tm1Hwu / Pten^tm1Hwu
	List all models in MMHCdb carrying the Nkx3-1^{tm4(cre/ERT2)Mms} allele Nkx3-1^{tm4(cre/ERT2)Mms} / Nkx3-1⁺

Models
7 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Prostate gland adenocarcinoma	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed - 10			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15 Sites of Metastasis: not (Unspecified organ) , not Bone , not Bone marrow , not Lung , not Lymph node , Bone marrow , Lymph node 8 pathology image(s)
Prostate gland adenocarcinoma in situ	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		30			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland metaplasia - squamous	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland prostatic intraepithelial neoplasia (PIN)	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		50			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland prostatic intraepithelial neoplasia - grade 3 (PIN III)	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15 2 pathology image(s)
Prostate gland prostatic intraepithelial neoplasia - grade 4 (PIN IV)	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland squamous cell papilloma	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15