Strain SummarySTOCK Kras^tm4Tyj/+ Nkx3-1^{tm4(cre/ERT2)Mms}/+ Pten^tm1Hwu

Strain Name	STOCK Kras^tm4Tyj/+ Nkx3-1^{tm4(cre/ERT2)Mms}/+ Pten^tm1Hwu
Strain Type(s)	targeted mutation (conditional) • targeted mutation (knock-in)
Strain Synonym(s)	Nkx3.1^CE2/+; Pten^f/f; Kras^12D/+ • Nkx3.1^CreERT2/+; Pten^flox/flox; Kras^G12D/+ • Nkx3.1^CreERT2/+; Pten^flox/flox; Kras^LSL-G12D/+ • Nkx3.1^CreERT2/+; Pten^flox/flox; Kras^12D/+ • NPK
Description	Compound mutant mice. This STOCK genetic background included C57BL/6, "129/Sv" (including 129S6/SvEvTac and 129S4/SvJae), and FVB.
Strain Genetics	List all models in MMHCdb carrying the Pten^tm1Hwu allele Pten^tm1Hwu / Pten^tm1Hwu
	List all models in MMHCdb carrying the Nkx3-1^{tm4(cre/ERT2)Mms} allele Nkx3-1^{tm4(cre/ERT2)Mms} / Nkx3-1⁺
	List all models in MMHCdb carrying the Kras^tm4Tyj allele Kras^tm4Tyj / Kras⁺

Models
8 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Prostate gland adenocarcinoma	Prostate gland			0			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland adenocarcinoma	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		72			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15 Sites of Metastasis: (Unspecified organ) , not Bone , Bone marrow , Kidney , Liver , Lung , Lymph node , Muscle - Striated - Skeletal - Diaphragm , Pancreas 36 pathology image(s)
Prostate gland adenocarcinoma in situ	Prostate gland			0			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland adenocarcinoma in situ	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		18			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland prostatic intraepithelial neoplasia (PIN)	Prostate gland			0			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland prostatic intraepithelial neoplasia (PIN)	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		8			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15
Prostate gland prostatic intraepithelial neoplasia - grade 3 (PIN III)	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15 1 pathology image(s)
Prostate gland prostatic intraepithelial neoplasia - grade 4 (PIN IV)	Prostate gland	tamoxifen (for inducing expression from mutant alleles)		observed			References: Aytes A, Proc Natl Acad Sci U S A 2013 Sep 10;110(37):E3506-15 1 pathology image(s)