Strain SummaryC57BL/6J-Krt14tm1.1(cre)Wbm/+ Rad51ctm1Sks/+ Trp53tm1Brn
Strain Name |
C57BL/6J-Krt14tm1.1(cre)Wbm/+ Rad51ctm1Sks/+ Trp53tm1Brn |
Strain Type(s) |
targeted mutation (conditional) • targeted mutation (knock-in) |
Strain Synonym(s) |
p53/K14cre • p53/K14cre • p53lox/lox; K14cre/+ • p53lox/lox; Rad51cneo/+; K14cre/+ • Trp53tm1Brn; Krt14tm1.1(cre)Wbm/+ |
Description |
Compound mutant mice. The genetic background of these mice was stated to be predominantly C57BL/6J but no backcrossing details were given. It also includes some 129P2/OlaHsd, 129S1/Sv, and possibly some NMRI. |
Strain Genetics |
Krt14tm1.1(cre)Wbm / Krt14+ |
Trp53tm1Brn / Trp53tm1Brn | |
Rad51ctm1Sks / Rad51c+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Ear - Zymbal gland carcinoma in situ | Ear - Zymbal gland |
0 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Ear - Zymbal gland squamous cell carcinoma | Ear - Zymbal gland |
0 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Eye - Meibomian gland squamous cell carcinoma | Eye - Meibomian gland |
0 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Mammary gland carcinoma | Mammary gland |
0 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Mammary gland tumor | Mammary gland |
observed |
References: Tumiati M, Oncogene 2016 Jan 25;(): |
|||||
Muzzle carcinoma - sebaceous | Muzzle |
0 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Preputial gland (male) carcinoma in situ | Preputial gland (male) |
0 - 5.3 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Preputial gland (male) hyperplasia | Preputial gland (male) |
15.8 - 40 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Preputial gland (male) squamous cell carcinoma | Preputial gland (male) |
10.5 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Skin lesion - benign | Skin |
5.3 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Skin papilloma | Skin |
5.3 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
Skin squamous cell carcinoma | Skin |
5.3 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |
|||||
(Unspecified organ) tumor | (Unspecified organ) |
15.8 - 29 |
References: Tumiati M, J Pathol 2015 Jan;235(1):136-46 |