Strain SummaryB6.Cg-Ptentm4.1Ppp/+

Strain Name

 B6.Cg-Ptentm4.1Ppp/+

Strain Type(s)

 congenic  •  targeted mutation (knock-in)

Strain Synonym(s)

 ge/+  •  PtenG129E/+  •  PtenG129E/+

Description

 Heterozygous mice. The genetic background of these mice was congenic C57BL/6. The ES cells used to generate the mutation were derived from (C57BL/6 x 129S4/SvJae)F1 mice.

Strain Genetics

 Ptentm4.1Ppp / Pten+

Models

43 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

91.9

86.5

References: Papa A, Cell 2014 Apr 24;157(3):595-610

CNS - Brain - Cerebellum hamartoma CNS - Brain - Cerebellum

25

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Clitoral gland squamous cell carcinoma Clitoral gland

10.53

References: Tumiati M, Oncogene 2016 Jan 25;():

Ear - Zymbal gland squamous cell carcinoma Ear - Zymbal gland

23.68

References: Tumiati M, Oncogene 2016 Jan 25;():

Eye - Meibomian gland squamous cell carcinoma Eye - Meibomian gland

5.26

References: Tumiati M, Oncogene 2016 Jan 25;():

Gallbladder papilloma Gallbladder

78.4

89.2

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Intestine polyp Intestine

86.5

83.8

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Leukocyte - Lymphocyte hyperplasia Leukocyte - Lymphocyte

85.7

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Leukocyte - Lymphocyte hyperplasia Lymph node

97.3

100

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Liver adenoma Liver

10.8 - 13.3

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland adenocarcinoma Mammary gland

24.3 - 37.5

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland adenomyoepithelioma Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma Mammary gland

63.16

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma - acinar Mammary gland

2.63

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma - adenosquamous Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma - cribriform Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma - glandular Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma - papillary Mammary gland

2.63

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinoma - solid Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland carcinosarcoma Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland cyst - squamous Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland hyperplasia Mammary gland

18.9

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland lesion Mammary gland

66.7

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland mammary intraepithelial neoplasia (MIN) Mammary gland

0 - 78.95

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland mammary intraepithelial neoplasia (MIN) - adenosquamous Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland mammary intraepithelial neoplasia (MIN) - high grade Mammary gland

28.57

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland mammary intraepithelial neoplasia (MIN) - low grade Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland mammary intraepithelial neoplasia (MIN) - solid Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland metaplasia - cartilaginous Mammary gland

observed

References: Tumiati M, Oncogene 2016 Jan 25;():

Mammary gland tumor Mammary gland

2.63

References: Tumiati M, Oncogene 2016 Jan 25;():

Mesodermal cell/mesoblast sarcoma Muscle

0

References: Tumiati M, Oncogene 2016 Jan 25;():

Muzzle carcinoma Muzzle

18.42

References: Tumiati M, Oncogene 2016 Jan 25;():

Pituitary gland adenoma Pituitary gland

25

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Prostate gland adenocarcinoma Prostate gland

13.5

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Prostate gland prostatic intraepithelial neoplasia (PIN) Prostate gland

54.1

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Skin lesion Skin

23.68

References: Tumiati M, Oncogene 2016 Jan 25;():

Skin squamous cell carcinoma Skin

52.63

References: Tumiati M, Oncogene 2016 Jan 25;():

Thyroid gland adenocarcinoma Thyroid gland

8.1

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Thyroid gland adenoma Thyroid gland

27.0

48.6

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Thyroid gland cyst Thyroid gland

54.1

45.9

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Uterus adenoma Uterus

51.4

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Uterus cyst Uterus

21.6

References: Papa A, Cell 2014 Apr 24;157(3):595-610

(Unspecified organ) tumor (Unspecified organ)

100

References: Tumiati M, Oncogene 2016 Jan 25;():