Strain Summary[not specified]-Gt(ROSA)26Sortm2(sb11)Njen Speer6-ps1Tg(Alb-cre)21Mgn/? TgTn(sb-T2/Onc)68Dla
Strain Name |
[not specified]-Gt(ROSA)26Sortm2(sb11)Njen Speer6-ps1Tg(Alb-cre)21Mgn/? TgTn(sb-T2/Onc)68Dla |
Strain Type(s) |
targeted mutation (conditional) • transgenic |
Strain Synonym(s) |
Alb-cre T2/Onc RLS • ATR • Alb-CreTg/WT; Rosa26-lsl-SB11Tg/WT; T2/OncTg/WT • SB-mutagenized |
Description |
Compound mutant mice. The genetic background of these mice was not specified but included at least some C57BL/6J, "129", FVB/N, and possibly some DBA and/or C57BL/6 (substrain unspecified). |
Strain Genetics |
Speer6-ps1Tg(Alb-cre)21Mgn / Speer6-ps1? |
Gt(ROSA)26Sortm2(sb11)Njen | |
TgTn(sb-T2/Onc)68Dla |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Liver - Bile duct cholangiocarcinoma | Liver - Bile duct | ethanol ⋅ choline-deficient |
0 |
References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588 |
||||
Liver hepatocellular adenoma | Liver | ethanol ⋅ choline-deficient |
observed |
References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588 |
||||
Liver hepatocellular carcinoma | Liver | ethanol ⋅ choline-deficient |
observed |
References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588 |
||||
Liver tumor | Liver | ethanol ⋅ choline-deficient |
81 |
65 |
76 |
References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588 |
||
Liver tumor | Liver | nitisinone (NTBC) |
40 |
78 |
References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588 |