Strain Summary[not specified]-Fahtm1Mgo Gt(ROSA)26Sortm2(sb11)Njen

Strain Name

 [not specified]-Fahtm1Mgo Gt(ROSA)26Sortm2(sb11)Njen

Strain Type(s)

 targeted mutation (conditional)  •  targeted mutation (knockout)

Strain Synonym(s)

 Fah-/- Rosa26-SB11  •  Fah/SB11  •  Fah-/-; Rosa26-SB11Tg/WT

Description

 Compound mutant mice. The genetic background of these mice was not specified but included at least some C57BL/6J, "129", and 129S7/SvEvBrd-Hprt+.

Strain Genetics

 Fahtm1Mgo / Fahtm1Mgo
Gt(ROSA)26Sortm2(sb11)Njen

Models

7 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Liver hepatocellular adenoma Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   nitisinone (NTBC)   ⋅   Sleeping Beauty transposon expressing Fah, firefly luciferase, and GFP (pkT2/GD-GFP)

14

7

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588

Liver hepatocellular adenoma Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   ethanol   ⋅   choline-deficient   ⋅   Sleeping Beauty transposon expressing Fah, firefly luciferase, and GFP (pkT2/GD-GFP)

12.5

30

22

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588

Liver tumor Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   Sleeping Beauty transposon expressing Nat10, Fah, firefly luciferase, and GFP (pT2/GD-Nat10)   ⋅   nitisinone (NTBC)

50

91

68

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588

Liver tumor Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   Sleeping Beauty transposon expressing Nat10, Fah, firefly luciferase, and GFP (pT2/GD-Nat10)   ⋅   ethanol   ⋅   choline-deficient

50

92

71

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588

Liver tumor Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   Sleeping Beauty transposon expressing PrkacaL206R, Fah, firefly luciferase, and GFP (pT2/GD/PrkacaL206R)   ⋅   nitisinone (NTBC)

17

43

31

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588

Liver tumor Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   Sleeping Beauty transposon expressing PrkacaL206R, Fah, firefly luciferase, and GFP (pT2/GD/PrkacaL206R)   ⋅   ethanol   ⋅   choline-deficient

20

78

52

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588

Liver tumor Liver Sleeping Beauty transposon expressing short hairpin against Trp53 and GFP (pT2/shp53)   ⋅   nitisinone (NTBC)   ⋅   Sleeping Beauty transposon expressing Fah, firefly luciferase, and GFP (pkT2/GD-GFP)

0

References: Tschida BR, Cancer Res 2017 Dec 1;77(23):6576-6588