Strain SummaryC57BL/6-Apc^tm1Mmt/+ Braf^tm1Mmcm/+Lgr5^{tm1(cre/ERT2)Cle}/+

Strain Name	C57BL/6-Apc^tm1Mmt/+ Braf^tm1Mmcm/+Lgr5^{tm1(cre/ERT2)Cle}/+
Strain Type(s)	targeted mutation (conditional) • targeted mutation (knock-in) • targeted mutation (knockout)
Strain Synonym(s)	BLM • BRAF^F-V600ELgr5^{tm1(Cre/ERT2)Cle}Min^Apc?716/+
Description	Heterozygous Apc, Braf, Lgr mice on a C57BL/6 background with contribution from 129P2/OlaHsd and 129S2/SvPas.
Strain Genetics	List all models in MMHCdb carrying the Apc^tm1Mmt allele Apc^tm1Mmt / Apc⁺
	List all models in MMHCdb carrying the Lgr5^{tm1(cre/ERT2)Cle} allele Lgr5^{tm1(cre/ERT2)Cle} / Lgr5⁺
	List all models in MMHCdb carrying the Braf^tm1Mmcm allele Braf^tm1Mmcm / Braf⁺

Models
16 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Intestine - Large Intestine - Colon - Distal tumor	Intestine - Large Intestine - Colon - Distal	Bacteroides fragilis			82.93 - 100		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon - Distal tumor	Intestine - Large Intestine - Colon - Distal				very low		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon - Distal tumor	Intestine - Large Intestine - Colon - Distal	Bacteroides fragilis ⋅ anti-PD-L1 (Cd274)			100		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon - Proximal tumor	Intestine - Large Intestine - Colon - Proximal	Bacteroides fragilis			9.76 - 97.56		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon - Proximal tumor	Intestine - Large Intestine - Colon - Proximal	Bacteroides fragilis ⋅ anti-PD-L1 (Cd274)			71.43		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon adenoma	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon adenoma - microadenoma	Intestine - Large Intestine - Colon	Bacteroides fragilis			86.67		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon adenoma - microadenoma	Intestine - Large Intestine - Colon				very low		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon adenoma - tubular	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon adenoma - villous	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon dysplasia	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon tumor	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed - 100		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon tumor	Intestine - Large Intestine - Colon				very low		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon tumor	Intestine - Large Intestine - Colon	Bacteroides fragilis ⋅ anti-PD-L1 (Cd274)			100		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon tumor - serrated	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():
Intestine - Large Intestine - Colon tumor - sessile	Intestine - Large Intestine - Colon	Bacteroides fragilis			observed		References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;():