Strain SummaryC57BL/6-Apctm1Mmt/+ Krastm4Tyj/+ Lgr5tm1(cre/ERT2)Cle/+
Strain Name |
C57BL/6-Apctm1Mmt/+ Krastm4Tyj/+ Lgr5tm1(cre/ERT2)Cle/+ |
Strain Type(s) |
targeted mutation (conditional) • targeted mutation (knockout) |
Strain Synonym(s) |
KrasG12DLgr5tm1(Cre/ERT2)CleMinApc?716/+ • KLM |
Description |
Heterozygous Apc, Kras, Lgr mice on a C57BL/6 background with contribution from 129P2/OlaHsd and 129S2/SvPas. |
Strain Genetics |
Apctm1Mmt / Apc+ |
Lgr5tm1(cre/ERT2)Cle / Lgr5+ | |
Krastm4Tyj / Kras+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Intestine - Large Intestine - Colon - Distal tumor | Intestine - Large Intestine - Colon - Distal | Bacteroides fragilis |
55.56 - 100 |
References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;(): |
||||
Intestine - Large Intestine - Colon - Proximal tumor | Intestine - Large Intestine - Colon - Proximal | Bacteroides fragilis |
11.11 - 33.33 |
References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;(): |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | Bacteroides fragilis |
77.78 |
References: DeStefano Shields CE, Cancer Discov 2021 Feb 25;(): |