Pathology Image Detail

Caption

 Small intestine: the intestinal epithelium is focally moderately thickened by a cauliflower-like 3 mm in diameter mass. This mass is composed of papillae (close to the surface) and glands (in the deeper portions of the adenoma) lined by a one cell-thick columnar epithelium supported by a small amount of fibrovascular stroma. There is no evidence of invasion in the stroma or in the submucosa.

Description

 Adenoma, small intestine

Age at Necropsy

 63 days

Contributor

 Kemp CJ (J:97126)

Pathologist

 Mikaelian I (J:94320)

Method

 H&E

Model
MMHC ID
MTB:25617
Tumor Name
Intestine - Small Intestine • adenoma
Treatment Type
None (spontaneous)
Tumor Synonyms
small intestine adenoma
Organ Affected
Intestine - Small Intestine
Frequency
observed
Reference
J:94320

Strain
Strain
C57BL/6-ApcMin/+ Cdkn1btm1Mlf
Strain Types
chemically induced mutation
targeted mutation (knockout)
General Note
Mice were heterozygous for the ApcMin allele and homozygous for the Cdkn1btm1Mlf allele. These mice are the product of an intercross between strains on a predominantly C57BL/6 background.
Strain Synonyms
Min/+ p27-/-
B6.Cg-ApcMin/+ Cdkn1btm1Mlf
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
63 days