Pathology Image Detail

Caption

Mammary gland, adenocarcinoma. Neoplastic cells labeling for alpha smooth muscle actin form a continuous row at the periphery of neoplastic lobules in this area with a comedo pattern. In addition, a moderate number of neoplastic cells randomly distributed in neoplastic lobules moderately label for alpha smooth muscle actin. A moderate number of myofibroblasts scattered in the stroma of the tumor and smooth muscle fibers of the wall of blood vessels also label for alpha smooth muscle actin.

Description

Mammary gland, adenocarcinoma.

Age at Necropsy

186 days

Contributor

Mikaelian I (J:94310)

Pathologist

Mikaelian I (J:94310)

Method

IHC for alpha smooth muscle actin
Image Probes

Type: antibody

Name
anti-alpha smooth muscle actin (A2547)
Target
alpha-smooth muscle actin, N-terminus
Supplier
Sigma-Aldrich
Notes
Monoclonal anti-Alpha Smooth Muscle Actin antibody produced in mouse (raised against N-terminal synthetic decapeptide of alpha-smooth muscle actin). The antibody (also known as anti-a-Sm-1) is specific for the single isoform of alpha-smooth muscle actin.

Model

MMHC ID
MTB:18036
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
mammary adenocarcinoma
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94310

Strain

Strain
C3H/HeJ
Strain Types
inbred
Strain Synonyms
C3H/HeJ-MTV+
C3H The Jackson Laboratory
C3H/HeJ, H-2k
C3H
C3H/He
C3H/HeJ MMTV-
C3H Heston
C3
C3H/HeJ mtv+
MTV+
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
186 days