Caption |
These animals were injected with BrdUrd (10 mg/kg body weight) 1 h before death, and analysis of BrdUrd incorporation demonstrated a significantly higher S-phase fraction (P < 0.05 for three matched pairs) in the Rb+/=; ARF-/- sample (D) relative to the Rb+/= control (C). |
Description |
Midsagittal section of a pituitary tumor stained with BrdUrd showing 15.3 +/- 4% positive nuclei. Only low levels of apoptosis were observed by either TUNEL staining or study of H&E stained slides. Tumor size and stage was similar to that found in 6.5 month old Rb1 heterozygote mouse. |
Age at Necropsy |
4.5 months |
Notes |
Fig 2D and text original source. |
Contributor |
Tsai KY (J:81016) |
Pathologist |
Tsai KY (J:81016) |
Copyright |
This image is from Tsai KY, Proc Natl Acad Sci USA 2002 Dec 24;99(26):16865-70. Copyright 2002 National Academy of Sciences, U.S.A. |
Method |
BRDU |