Pathology Image Detail

Caption

 Type A spindle cell adrenocortical carcinoma. The details of the cell type can be seen here. Some cells are spindle shaped with elongated oval nuclei. Cytoplasmic boundries are difficult to identify. Mitotic figures (circles) are frequent. Some pink cortical cells remain but most are lost due to expansion and compression of the primary neoplasm.

Description

 Type A spindle cell adrenocortical carcinoma

Age at Necropsy

 389 days

Contributor

 Mikaelian I (J:94310)

Pathologist

 Mikaelian I (J:94310)

Method

 H&E

Model
MMHC ID
MTB:18397
Tumor Name
Adrenal gland - Cortex • carcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
adrenocortical carcinoma
Organ Affected
Adrenal gland - Cortex
Frequency
observed
Reference
J:94310

Strain
Strain
C.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Homozygous mice. These mice have been fully backcrossed onto BALB/cJ. The original mutation was generated using 129S2/SvPas ES cells and was crossed to C57BL/6 before being backcrossed to BALB/cJ.
Strain Synonyms
BALB/cJ-Trp53tm1Tyj
C.129S2(B6)-Trp53tm1Tyj
C.129S2-Trp53tm1Tyj/J
p53&delta
BALB-p53?/?
p53-/-
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
389 days