Pathology Image Detail

Caption

 This high magnification allows to detail cytologic features of neoplastic cells. Neoplastic cells are closely-packed, round, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, round, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. Mitotic index is high. Numerous neoplastic cells undergo single cell necrosis, giving a starry-sky appearance to the neoplasm.

Description

 Pancreatic lymph node, lymphoma.

Age at Necropsy

 108 days

Contributor

 Mikaelian I (J:94314)

Pathologist

 Mikaelian I (J:94314)

Method

 H&E

Model
MMHC ID
MTB:18474
Tumor Name
Leukocyte - Lymphocyte • lymphoma
Treatment Type
None (spontaneous)
Tumor Synonyms
lymphoma
Organ Affected
Lymph node
Frequency
observed
Reference
J:94314

Strain
Strain
C.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Homozygous mice. These mice have been fully backcrossed onto BALB/cJ. The original mutation was generated using 129S2/SvPas ES cells and was crossed to C57BL/6 before being backcrossed to BALB/cJ.
Strain Synonyms
BALB/cJ-Trp53tm1Tyj
C.129S2(B6)-Trp53tm1Tyj
C.129S2-Trp53tm1Tyj/J
p53&delta
BALB-p53?/?
p53-/-
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
108 days