Pathology Image Detail

Caption	Fig. 5R Immunohistochemistry for TRP63 in prostate tissues of 4-week-old Pten^loxP/loxP:Osr1-Cre mice.
Description	high-grade PIN; immunohistochemical analysis of Pten and Trp63 in adjacent slides
Notes	Fig. 5Q,R
Contributor	Kwak MK (J:195810)
Pathologist	Kwak MK (J:195810)
Copyright	This image is from Kwak MK, PLoS One 2013;8(1):e53476, an open-access article distributed under the terms of the Creative Commons Attribution License.
Method	IHC for TRP63

Image Probes
Type: antibody	Name anti-p63 (4A4) (sc-8431) Target amino acids 1-205 at the N-terminus of human p63 Supplier Santa Cruz Biotechnology Notes mouse monoclonal IgG2a; "recommended for detection of p63 variants of m[ouse], r[at] and h[uman] origin"

Model

MMHC ID: MTB:60992

Tumor Name: Prostate gland • prostatic intraepithelial neoplasia - high grade (HGPIN)

Treatment Type: None (spontaneous)

Tumor Synonyms: high grade PIN; high-grade prostatic intraepithelial neoplasia (PIN); dysplastic lesions in the prostate gland

Organ Affected: Prostate gland

Frequency: 100%

Reference: J:195810

Strain

Strain: B6.Cg-Pten^tm1Hwu Tg(Osr1-cre)4Mrt

Strain Types: targeted mutation (conditional); transgenic

General Note: Compound mutant mice. These mice had been backcrossed more than 5 times to C57BL/6J and then intercrossed. The genetic background also may include some 129S4/SvJae, FVB/N, and BALB/c.

Strain Synonyms: Pten^loxP/loxP;Osr-1Cre; pten^loxP/loxPOsr-1Cre; Pten^loxP/loxPOsr-1Cre+; Pten^loxP/loxP:Osr1-Cre

Strain Sex: Male

Reproductive Status: reproductive status not specified

Age of Detection: 1 month (4 weeks)