Pathology Image Detail

Caption

Heart - normal tissue. Endocardium (heart): there is moderate cytoplasmic immunolabeling of endothelial cells of the aorta for platelet-derived growth factor alpha (antibody diluted at 1:25, tissue fixed in IHC Zinc fixative, heat-mediated antigen retrieval in citrate buffer at pH=6.0). This pattern of labeling was consistently detected with this antibody but may represent an artifact.

Description

Heart - Normal tissue. Platelet-derived growth factor alpha immunohistochemistry, heart, endocardium

Age at Necropsy

35 days

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

IHC for platelet-derived growth factor alpha (PDGFA)
Image Probes

Type: antibody

Name
anti-PDGF-A (E-10) (sc-9974)
Target
platelet-derived growth factor alpha (PDGFA)
Supplier
Santa Cruz Biotechnology
Notes
Mouse monoclonal IgG2b raised against amino acids 135-211 mapping at the C-terminus of PDGFA of human origin.

Model

MMHC ID
MTB:27647
Tumor Name
Heart • normal tissue (control)
Treatment Type
None (spontaneous)
Tumor Synonyms
heart, normal tissue
Organ Affected
Heart
Frequency
not applicable
Reference
J:94320

Strain

Strain
C57BL/6J
Strain Types
inbred
Strain Synonyms
wild-type C57BL/6J
C57Bl/6J
p53+/+
C57BL/6 from Jackson Laboratory
C57BL/6
B6
C57/Bl6
C57
C57BL/6J (F129+51)
C57 black subline 6
B/6
Bl/6
C57BL/6J wild-type
WT
Black 6
C57 Black
wild type
C57BL/6J+/+
p53 wild-type (+/+)
C57BL6/J
C57BL/6J, H-2b
C57/B16
wild-type
C57BL
B6 WT
wild-type (WT)
WT-Control
WT-CR
C57/Bl 6J
C57/Bl
p21+/+p27+/+
control
Ctr
C57BL/6J (UW)
B6J
C57BL/6J inbred WT
C57 BL/6
Wild-type (WT) C57BL/6J
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified
Age of Detection
35 days