Pathology Image Detail

Caption

Colon - normal tissue. There is moderate labeling of the colonic epithelium with an antibody which recognizes a wide spectrum of keratins (tissue fixed in Fekete's solution, trypsin digestion, 1:50 dilution). Labeling is stronger in colonic glands than in the surface epithelium. This antibody did not label all the structures it was supposed to label based on published information concerning keratin expression in mouse tissues.

Description

Intestine - Large Intestine - Colon -Normal tissue. Keratins (broad spectrum) immunohistochemistry

Age at Necropsy

unknown

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

IHC for keratins 4, 5, 6, 8, 10, 13, & 18
Image Probes

Type: antibody

Name
anti-cytokeratin 4, 5, 6, 8, 10, 13 & 18 monoclonal anitbody (CBL234)
Target
human cytokeratin 4, 5, 6, 8, 10, 13 & 18
Supplier
Chemicon
Notes
mouse IgG1 monoclonal antibody. Cclone C11. Also known to cross react with bovine, rat and frog keratins.

Model

MMHC ID
MTB:27723
Tumor Name
Intestine - Large Intestine - Colon • normal tissue (control)
Treatment Type
None (spontaneous)
Tumor Synonyms
colon, normal tissue
Organ Affected
Intestine - Large Intestine - Colon
Frequency
not applicable
Reference
J:94320

Strain

Strain
C57BL/6J
Strain Types
inbred
Strain Synonyms
wild-type C57BL/6J
C57Bl/6J
p53+/+
C57BL/6 from Jackson Laboratory
C57BL/6
B6
C57/Bl6
C57
C57BL/6J (F129+51)
C57 black subline 6
B/6
Bl/6
C57BL/6J wild-type
WT
Black 6
C57 Black
wild type
C57BL/6J+/+
p53 wild-type (+/+)
C57BL6/J
C57BL/6J, H-2b
C57/B16
wild-type
C57BL
B6 WT
wild-type (WT)
WT-Control
WT-CR
C57/Bl 6J
C57/Bl
p21+/+p27+/+
control
Ctr
C57BL/6J (UW)
B6J
C57BL/6J inbred WT
C57 BL/6
Wild-type (WT) C57BL/6J
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified
Age of Detection
unknown