Pathology Image Detail

Caption

Colon - normal tissue. There is strong nuclear immunolabeling for PCNA of epithelial cells of colonic glands (antibody diluted at 1:100, tissue fixed in Fekete's solution). There is mild cytoplasmic background in smooth muscle fibers of the muscular mucosae.

Description

Intestine - Large Intestine - Colon -Normal tissue. Proliferating cell nuclear antigen immunohistochemistry

Age at Necropsy

35 days

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

IHC for proliferating cell nuclear antigen (PCNA)
Image Probes

Type: antibody

Name
anti-PCNA (PC10) (sc-56)
Target
proliferating cell nuclear antigen (PCNA) p36 protein [mouse, rat, human, insect, & S. pombe]
Supplier
Santa Cruz Biotechnology
Notes
"Mouse monoclonal IgG2a antibody derived by fusion of spleen cells from a BALB/c mouse with recombinant PCNA with Sp2/0-Ag14 myeloma cells."

Model

MMHC ID
MTB:27651
Tumor Name
Intestine - Large Intestine - Colon • normal tissue (control)
Treatment Type
None (spontaneous)
Tumor Synonyms
colon, normal tissue
Organ Affected
Intestine - Large Intestine - Colon
Frequency
not applicable
Reference
J:94320

Strain

Strain
C57BL/6J
Strain Types
inbred
Strain Synonyms
wild-type C57BL/6J
C57Bl/6J
p53+/+
C57BL/6 from Jackson Laboratory
C57BL/6
B6
C57/Bl6
C57
C57BL/6J (F129+51)
C57 black subline 6
B/6
Bl/6
C57BL/6J wild-type
WT
Black 6
C57 Black
wild type
C57BL/6J+/+
p53 wild-type (+/+)
C57BL6/J
C57BL/6J, H-2b
C57/B16
wild-type
C57BL
B6 WT
wild-type (WT)
WT-Control
WT-CR
C57/Bl 6J
C57/Bl
p21+/+p27+/+
control
Ctr
C57BL/6J (UW)
B6J
C57BL/6J inbred WT
C57 BL/6
Wild-type (WT) C57BL/6J
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified
Age of Detection
35 days