Pathology Image Detail

Caption

 Fig. 3A. Stomach: the surface of the glandular portion of the stomach is covered by numerous coalescing polyps of different sizes. The non-glandular portion of the stomach (top) is unaffected.

Description

 Hamartoma, polypoid, glandular stomach

Age at Necropsy

 280 days

Contributor

 Miyoshi H (J:76202)

Pathologist

 Mikaelian I (J:94320)

Copyright

 Reprinted by permission from the American Association for Cancer Research: Miyoshi H et al., "Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice." Cancer Res 2002 Apr 15;62(8):2261-6.

Method

 Macroscopic slide

Model
MMHC ID
MTB:24824
Tumor Name
Stomach - Glandular • hamartoma
Treatment Type
None (spontaneous)
Tumor Synonyms
hamartoma, polypoid, glandular stomach
Organ Affected
Stomach - Glandular
Frequency
observed
Reference
J:76202

Strain
Strain
[not specified]-Stk11tm1Mmt/+
Strain Types
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background was not specified. It contains 129X1/SvJ (from the ES cell of origin of the targeted mutant allele).
Strain Synonyms
Lkb1 heterozygous knockout
Lkb1 (+/-)
Lkb1+/-
Lkb1+/-
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
280 days