Pathology Image Detail

Caption

 Fig. 3G. Intestinal hamartoma: this is high magnification photomicrograph of the basal portions of an intestinal hamartoma. Cells forming the glands often contain a large apical mucus droplet (goblet cell metaplasia). There is no evidence of atypia or of local invasion. Mitotic rate is high.

Description

 Hamartoma, polypoid, small intestine

Age at Necropsy

 280 days

Contributor

 Miyoshi H (J:76202)

Pathologist

 Mikaelian I (J:94320)

Copyright

 Reprinted by permission from the American Association for Cancer Research: Miyoshi H et al., "Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice." Cancer Res 2002 Apr 15;62(8):2261-6.

Method

 H&E

Model
MMHC ID
MTB:24825
Tumor Name
Intestine - Small Intestine • hamartoma
Treatment Type
None (spontaneous)
Tumor Synonyms
hamartoma, polypoid, small intestine
Organ Affected
Intestine - Small Intestine
Frequency
observed
Reference
J:76202

Strain
Strain
[not specified]-Stk11tm1Mmt/+
Strain Types
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background was not specified. It contains 129X1/SvJ (from the ES cell of origin of the targeted mutant allele).
Strain Synonyms
Lkb1 heterozygous knockout
Lkb1 (+/-)
Lkb1+/-
Lkb1+/-
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
280 days