Pathology Image Detail

Caption

Fig. 1C. Liver: the architecture of the liver is focally effaced by a multilobular, unenecapsulated, expensile, non-compressive, densely cellular mass. This mass is composed of 2-3 cells thick interconnected trabeculae separated by sinusoids. Cells are large, polygonal, with distinct cell borders and with a large amount of strongly acidophilic cytoplasm.

Description

Focus, acidophilic, liver

Age at Necropsy

unknown

Contributor

Nakau M (J:78502)

Pathologist

Mikaelian I (J:94320)

Copyright

Reprinted by permission from the American Association for Cancer Research: Nakau M et al., "Hepatocellular carcinoma caused by loss of heterozygosity in lkb1 gene knockout mice." Cancer Res 2002 Aug 15;62(16):4549-53.

Method

H&E

Model

MMHC ID
MTB:24826
Tumor Name
Liver • foci - acidophilic
Treatment Type
None (spontaneous)
Tumor Synonyms
focus, acidophilic, liver
Organ Affected
Liver
Frequency
observed
Reference
J:78502

Strain

Strain
B6;129-Stk11tm1Mmt/+
Strain Types
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background was a mix of C57BL/6, 129X1/SvJ, and possibly some other unspecified "129/Sv" substrain.
Strain Synonyms
Lkb1 heterozygote
Lkb1 (+/-)
Lkb1 +/-
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified